Archive | 2019
Observation of prolactin and estradiol levels in lactating women in different iodine nutrition areas
Abstract
Objective \nTo observe prolactin (PRL) and estradiol (E2) levels in lactating women in different iodine nutrition areas. \n \n \nMethods \nAccording to the recent national water-borne high iodine area survey and the monitoring results of iodine deficiency disorders, the following places were selected, including Nankang, Xinggang and Yingpan towns of Beihai City, Guangxi (water iodine≤10 μg/L, low iodine areas), Yangcheng Township and Jiajiazhuang Township of Fenyang City, Shanxi (water iodine 50-100 μg/L, adaptive iodine areas), Pingyao County and Jicun Town of Fenyang City, Shanxi (water iodine ≥300 μg/L, high iodine areas), and urinary and blood samples were collected in lactating women (n=100, 97, 123) from the three regions. The urinary iodine concentration was tested by arsenic cerium catalytic spectrophotometry. Serum levels of PRL and E2 were determined by chemiluminescence immunoassay. \n \n \nResults \nThe urinary iodine medians of lactating women were 51.42, 283.62, 842.31 μg/L, respectively, in the three regions, the difference between the regions was statistically significant (χ2=241.09, P < 0.05); the iodine levels of lactating women in low iodine areas, adaptive iodine areas and high iodine areas were in the state of iodine deficiency (< 100 μg/L), sufficient or adequate (200-299 μg/L) and iodine excess status (≥300 μg/L), respectively. Serum PRL and E2 levels of lactating women in the three types of areas were 38.81, 20.98, 16.41 μg/L and 29.57, 43.70, 45.51 ng/L, respectively. The differences between the regions were statistically significant (χ2=41.54, 24.03, P < 0.05). \n \n \nConclusion \nWith the increase of iodine nutrition level, PRL in lactating women has presented a gradually decreasing trend, E2 is increased. \n \n \nKey words: \nIodine;\xa0Lactating women;\xa0Prolactin;\xa0Estradiol