Clinical research on the application of growth hormone in the preparation of thin endometrium

Abstract

Objective \nTo explore the effectiveness of growth hormone (GH) combined with hormone replacement therapy in thin endometrium patients prepararing for frozen-thawed embryo transfer (FET). \n \n \nMethods \nProspective cohort study was performed. Totally 214 patients who had been treated in Reproductive Center of Jiuzhou Perfect Hospital of Shenyang from January 2017 to June 2019, cancelled fresh cycle transplantation due to endometrial thickness less than 7 mm on the day of human chorionic gonadotropin (hCG) administration in previous fresh cycle, were divided into three groups according to their wishes: group A, hormone replacement combined with intrauterine perfusion of growth hormone (n=76); group B, hormone replacement combined with subcutaneous injection of GH (n=72); group C, single hormone replacement therapy (n=66). The basic situation of patients and prognostic indicators of FET among the three groups were compared. \n \n \nResults \nThere was no significant difference in age, infertility duration, body mass index (BMI), basic follicular stimulating hormone (FSH), basic luteinizing hormone (LH) and basic estrogen among the three groups (P>0.05). And there was no significant difference in the number of embryos transferred, the number of high-quality embryos transferred and the thickness of endometrium before treatment (P>0.05). After treatment, endometrial thickness of group A [(7.7±0.8) mm] was higher than that of group B [(7.3±0.8) mm, P=0.002] and group C [(6.7±0.9) mm, P 0.05). The cancellation rate of cycle in group C (33.33%) was higher than that in group A (13.16%) and group B (18.06%), and the pregnancy rate in group A (48.48%) was higher than that in groups B and C (28.81%, 27.27%), the differences were statistically significant among the three groups (P=0.010, P=0.027). But there was no significant difference in abortion rate among the three groups (P>0.05). \n \n \nConclusion \nIn FET cycle, hormone replacement combined with GH intrauterine perfusion can increase endometrial thickness, improve thin endometrial blood flow, and the operation is simple. \n \n \nKey words: \nReproductive techonology, assisted;\xa0Thin endometrium;\xa0Growth hormone