[Vital role of RIP3 in the mechanism of myocardial cell necroptosis].

Abstract

OBJECTIVE\nMyocardial ischemia/reperfusion (I/R) injury seriously endangers human health and is a potential hidden danger in the treatment of cardiovascular diseases, among which myocardial necrosis is one of the mechanisms of myocardial I/R injury. Numerous studies have shown that necrosis factor is widely involved in the regulation of myocardial cell necrosis, but its specific mechanism is not fully understood. Receptor interacting protein 3/receptor interacting protein kinase 3 (RIP3/RIPK3) is an essential protein in necroptosis pathways, and activated RIP3 can cause irreversible necrosis of myocardial cells. On the basis of introducing RIP3 molecule, this paper focused on the role and mechanism of RIP3 mediated necroptosis pathway in myocardial cell necroptosis, with a view to providenew ideas and insights for the treatment of myocardial I/R injury.