Importancia de las mutaciones del gen BRCA1 Y 2 en el cáncer de mama

Abstract

The objective of this research is to provide an updated review of the most important concepts of gene mutations, BRCA1 breast cancer gene 1 or BRCA2, breast cancer gene 2, however, since there is a close correlation with ovarian cancer Given by these mutations, we will also address general information about ovarian cancer and provide the tools and diagnostic keys for the timely identification of the pathology. A systematic search of recent research was carried out in Elsevier, Pubmed and Scopus databases of articles published between 2016 and 2020, in English and Spanish. Clinical trials, meta-analyzes, case reports, and data analysis studies were excluded. BRCA1s are associated with more aggressive types with a poorer prognosis of cancer, for this reason breast cancers diagnosed at an early age are indicated for genetic testing, and BRCA2s seem to have a less hereditary relationship, although they develop it at a later age However, the prevalence of BRCA1 and BRCA2 mutations varies according to the country and ethnic group, Ashkenazi Jews, of European origin and countries such as Iceland, Canada, Poland and the Netherlands that have been amplifying in the generations, contributing to this the geographic isolation of the population.