Clinical value of 18F-FDG PET/CT in postoperative colorectal cancer patients with elevated serum carcinoembryonic antigen

Abstract

Objective \nTo explore the value of 18-fluorine flurodeoxyglucose (18F-FDG) positron-emission tomography (PET)/computed tomography (CT) in detecting recurrence and metastasis in postoperative colorectal cancer patients with elevated serum carcinoembryonic antigen (CEA). \n \n \nMethods \nClinical data of 60 cases of colorectal cancer, including PET/CT, pathological, and follow-up results, were analyzed retrospectively. \n \n \nResults \nThere were 50 18F-FDG PET/CT positive and 10 18F-FDG PET/CT negative cases, including 1 false positive and 3 false negative cases. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18F-FDG PET/CT in detecting recurrence and metastasis in postoperative colorectal cancer patients with elevated serum CEA were 94.2%(49/52), 87.5% (7/8), 98.0% (49/50), 70.0% (7/10), and 93.3% (56/60), respectively. \n \n \nConclusion \n18F-FDG PET/CT has high clinical value in postoperative colorectal cancer patients with elevated serum CEA, and it has a high sensitivity, specificity, and accuracy in the detection of recurrence and metastasis. \n \n \nKey words: \nColorectal neoplasms;\xa0Recurrence;\xa0Neoplasm metastasis;\xa0Positron-emission tomography;\xa0Tomography, X-ray computed;\xa0Carcinoembryonic antigen