Archive | 2019
The clinicopathological and prognosis of elderly patients lung cancer with bone metastases
Abstract
Objective \nTo analyze the features and prognosis of elderly patients lung cancer with bone metastases. \n \n \nMethods \nThe clinical-pathological data of elderly patients lung cancer with bone metastases were retrospectively collected. Gender, pathological type, location of tumors, smoking status, the primary focus operation, the alkaline phosphatase (ALP), number of bone metastases, radiotherapy or chemotherapy status and TNM stage were recorded. The log-rank tests were performed to compare survival curves. Multivariate analyses were conducted to identify significant independent prognostic factors for the prognosis. \n \n \nResults \nThe average survival time of elderly patients lung cancer with bone metastases was 12 months. Univariate analysis showed significant relationships between the OS and the pathological type (χ2=4.178, P=0.041), the primary focus operation (χ2=7.980, P=0.005), the alkaline phosphatase (ALP) (χ2=6.814, P=0.009), the number of bone metastases (χ2=13.592, P<0.001) and the stages (χ2=10.060, P=0.018). Multivariate analysis results demonstrated ALP (HR=2.345, P=0.002) and the number of bone metastases (HR=1.987, P=0.001) were independent prognostic factors. \n \n \nConclusion \nThe prognosis of elderly lung cancer patients with bone metastases was poor, ALP and the number bone metastases can predict the prognosis. \n \n \nKey words: \nAged;\xa0Lung neoplasms;\xa0Alkaline phosphatase;\xa0Bone metastasis