Investigation Of The Effects Of Propofol/Ketamine Versus Propofol/Fentanyl On Nausea-Vomiting Administered For Sedation In Children Undergoing Magnetic Resonance Imaging: A Prospective Randomized Double-Blinded Study.

Abstract

PURPOSE\nIn this study, we aimed to compare the effects of propofol-ketamine and propofol-fentanyl sedations on post-procedure nausea-vomiting in children undergoing magnetic resonance imaging (MRI).\n\n\nMATERIALS AND METHODS\nThis study included 100 pediatric patients (2-10 years old) who had propofol-ketamine and propofol-fentanyl for sedation to undergo MRI. The patients were divided into two groups, and sedation was performed through propofol-ketamine (Group K; n=50) or propofol-fentanyl (Group F; n=50). For sedation induction, intravenous (IV) bolus of 1.2 mg/kg propofol and 1 mg/kg ketamine were administered in Group K, IV bolus of 1.2 mg/kg propofol and 1 µg/kg fentanyl in Group F. All patients received 0.5 mg/kg IV bolus propofol in additional doses when the Ramsey Sedation Score (RSS) was below 4 for maintenance. Perioperative heart rate, systolic arterial pressure, peripheral oxygen saturation, respiratory rate, and nausea-vomiting scores were recorded for each patient.\n\n\nRESULTS\nThere was no difference between the groups in terms of nausea incidences at the 1st hour. However, the rate of vomiting was significantly higher in Group K.\n\n\nCONCLUSION\nIn our study, we showed that the vomiting rate was higher in the 1st hour in Group K compared to Group F.