Turkish journal of medical sciences | 2021
Cross-cultural adaptation, reliability, and validity of the Turkish version of the obesity-specific quality of life questionnaire: quality of life, obesity and dietetics (QOLOD) rating scale.
Abstract
Background /aim: Acromegaly is a rare chronic endocrine disorder, the active form of which is associated with an increased risk of cardiovascular and metabolic disease. Therefore, early diagnosis and treatment of cardiovascular diseases in acromegaly patients are important in terms of morbidity and mortality. The aim of this study was to determine whether the visceral adiposity index (VAI), lipid accumulation product (LAP), and plasma atherogenic index (PAI) are early cardiovascular risk markers in patients with active acromegaly.\n\n\nMATERIALS AND METHODS\nThe study included 45 patients newly diagnosed with acromegaly and 45 age?sex matched healthy control subjects. The VAI, LAP, and PAI values were calculated, and carotid artery intima media thickness (CIMT) was measured in both the patients and control groups.\n\n\nRESULTS\nThe PAI, VAI, LAP, and CIMT values were significantly higher in patients with acromegaly compared with the control subjects (p < 0.004, p < 0.027, p <0.012, and p <0.001, respectively). In the patient group, a significant positive correlation was found between the growth hormone (GH), and insulin-like growth factor I (IGF-I) levels, and the VAI, LAP, and PAI values. A significant positive correlation was determined between CIMT, and LAP values in the patient group.\n\n\nCONCLUSION\nCIMT is a non-invasive method used to show early atherosclerosis. However, it is operator dependent. Therefore, VAI, LAP and PAI can be used as non-invasive, simple measurement methods to evaluate early atherosclerosis in patients with acromegaly.