Research progress of sodium hydrogen exchange protein-1 and its inhibitors

Abstract

Sodium hydrogen exchange protein-1 (NHE-1) is a cell membrane protein that is mainly distributed in human and mammalian cardiomyocytes, regulating intracellular and extracellular ion exchange. Nowadays, more and more basic research has confirmed that this protein plays an important role in the occurrence and development of various cardiovascular diseases, especially heart failure, cardiac hypertrophy, and coronary heart disease. Although the results of many clinical studies on NHE-1 inhibitors have been unsatisfactory for more than a decade, we should summarize and analyze these results dialectically and to find their true clinical significance. \n \n \nKey words: \nSodium hydrogen exchange protein-1;\xa0Myocardial reperfusion injury;\xa0Myocardial hypertrophy