Comparative Study of 4-Compartmental PK-PD Model with Effective Site Compartment for Different Parameter Set

Abstract

Target-controlled\ufeffinfusion\ufeffpumps\ufeffare\ufefffor\ufeffpatients\ufeffto\ufeffcontrol\ufeffpain\ufeffor\ufeffto\ufeffinfuse\ufeffsedations\ufeffand\ufeffanesthesia,\ufeff typically\ufeffthose\ufeffwho\ufeffunderwent\ufeffsurgery.\ufeffThe\ufeffpump\ufeffhas\ufeffa\ufeffprogrammable\ufeffsyringe\ufeffdevice\ufeffused\ufeffto\ufeffcontrol\ufeff the\ufeffinjection\ufefflevel\ufeffof\ufeffdrugs.\ufeffThese\ufeffpumps\ufeffare\ufeffeven\ufeffused\ufeffin\ufeffthe\ufeffICU\ufeffor\ufeffoperating\ufefftheaters\ufeffto\ufeffmanage\ufeff patient’s\ufeffpain\ufeffafter\ufeffsurgery\ufeffor\ufeffsedation.\ufeffPK-PD\ufeffModels\ufeffare\ufeffused\ufeffto\ufeffobtain\ufeffthe\ufeffdrug\ufeffconcentrations\ufefflevels\ufeff of\ufeffthe\ufeffpatient.\ufeffThe\ufeffmodel\ufeffdepends\ufeffon\ufeffthe\ufeffdrug\ufeffflow\ufeffrates\ufeffin\ufeffdifferent\ufeffparts\ufeffof\ufeffthe\ufeffbody.\ufeffThere\ufeffare\ufeffmany\ufeff parameter\ufeffsets\ufeffavailable\ufeffto\ufeffmeasure\ufeffthe\ufeffamount\ufeffof\ufeffdrugs\ufeffin\ufeffthe\ufeffpatients.\ufeffThis\ufeffarticle\ufeffpresents\ufeffa\ufeffthree\ufeff compartmental\ufeffpatient\ufeffmodel\ufeffthrough\ufeffSimulink\ufeffto\ufeffobtain\ufeffconcentrations\ufefflevels\ufefffrom\ufeffdifferent\ufeffparts\ufeff of\ufeffthe\ufeffbody.\ufeffThe\ufeffmodel\ufeffis\ufeffchecked\ufefffor\ufeffa\ufeffseven\ufeffparameter\ufeffset\ufeffand\ufeffsuggests\ufeffthe\ufeffset\ufeffwith\ufeffthe\ufeffbest\ufeffresults. KEywoRDS 3-compartmemental model, Anesthesia, PK-PD model, Target Controlled Infusion(TCI) INTRoDUCTIoN Based\ufeffon\ufeffseverity\ufeffof\ufeffdisease\ufeff(Khanday\ufeffet\ufeffal.,\ufeff2016)\ufeffthe\ufeffdrug\ufeffcan\ufeffbe\ufeffgiven\ufeffto\ufeffthe\ufeffpatient\ufeffeither\ufeffthrough\ufeff oral\ufeffor\ufeffintravenous\ufeff(IV).\ufeffWhen\ufeffa\ufeffdrug\ufeffis\ufeffinfused\ufeffthrough\ufeffIV\ufeffline,\ufeffit\ufeffwill\ufeffbe\ufeffdistributed\ufeffamong\ufeffdifferent\ufeff parts\ufeffof\ufeffthe\ufeffbody.\ufeffAccording\ufeffto\ufeffpharmacokinetics\ufeffstudies,\ufeffthe\ufeffinfused\ufeffmedicine\ufeffpassed\ufeffthrough\ufeffhuman\ufeff body\ufeffis\ufeffabsorbed,\ufeffdistributed\ufeffand\ufeffeliminated.\ufeffThe\ufeffmathematical\ufeffmodeling\ufeffof\ufeffdrug\ufeffconcentration\ufeffis\ufeffa\ufeff predictive\ufefftool\ufefffor\ufeffanalysis\ufeffof\ufeffbiological\ufeffprocesses.\ufeffModeling\ufeffthe\ufeffdrug\ufeffinfusion\ufeffhelps\ufeffto\ufeffadd\ufeffintelligence\ufeff to\ufeffinfusion\ufeffdevice\ufeffand\ufeffinteroperability\ufefffeature\ufeffto\ufeffthe\ufeffdevice.\ufeffFor\ufeffexample,\ufeffPatient\ufeffControlled\ufeffInfusion\ufeff (PCA)\ufeffis\ufeffa\ufeffself-controlled\ufeffinfusion\ufeffpump\ufeffused\ufeffto\ufeffinfuse\ufeffhigh\ufeffalert\ufeffsedations\ufeffor\ufeffdrugs\ufeffto\ufeffpatients.\ufeff Once\ufeff the\ufeffdrug\ufeff is\ufeffadministrated,\ufeff the\ufeffmicrocontroller\ufeffprogrammed\ufeffpump\ufeffwill\ufeffautomatically\ufeff infuse\ufeff the\ufeffmedicine\ufeffin\ufeffto\ufeffthe\ufeffpatient.\ufeffThe\ufeffinfusion\ufeffof\ufefftoo\ufeffmuch\ufeffdrug\ufeffinto\ufeffthe\ufeffpatient\ufeffmay\ufeffcause\ufeffadverse\ufeff events\ufefflike\ufeffdeath,\ufeffrespiratory\ufeffdepression\ufeffand\ufeffcoma.\ufeffThe\ufeffpump\ufeffeven\ufeffinvolves\ufeffmany\ufeffmedical\ufefferrors\ufeff like\ufeffprogrammable\ufefferrors\ufeffand\ufeffprescription\ufefferrors\ufeffetc.\ufeffWith\ufeffthese\ufeffabnormalities\ufeffin\ufeffinfusion\ufeffpumps,\ufeff more\ufeffattention\ufeffof\ufeffcontinuous\ufeffmonitoring\ufeffof\ufeffphysiological\ufeffparameter\ufeffof\ufeffpatients\ufeffis\ufeffneeded\ufeffto\ufeffcontrol\ufeff overdosed\ufeffhigh\ufeffalerts\ufeff(like\ufeffrespiratory\ufeffdepression)\ufeffwhile\ufeffinfusing\ufeffthrough\ufeffIV\ufefffluids\ufeff(Shola\ufeff&\ufeffV,\ufeff2017). Anesthesia\ufeffis\ufeffa\ufeffdrug\ufeffis\ufeffused\ufeffbefore\ufeffsurgery\ufeffthrough\ufeffinfusion\ufeffpumps.\ufeffThis\ufeffis\ufeffused\ufeffto\ufeffprovide\ufeffpainless\ufeff surgery\ufeffto\ufeffthe\ufeffpatient\ufeffand\ufeffsmooth\ufeffoperation.\ufeffWhen\ufeffinfusing\ufeffthese\ufeffkinds\ufeffof\ufeffdrugs\ufeffadministrator\ufeffmay\ufeff use\ufeffdifferent\ufeffranges\ufeffof\ufeffinfusions.\ufeffHowever,\ufeffproviding\ufeffthe\ufeffoptimum\ufeffdrug\ufeffdelivery\ufefflevels\ufeffand\ufeffsteady\ufeff state\ufeffblood\ufeffconcentrations\ufeffwhile\ufeffinfusing,\ufeffis\ufeffimportant\ufefffor\ufeffsafest\ufeffuse\ufeffof\ufeffpump.\ufeffThis\ufeffpaper\ufeffpresents\ufeffthe\ufeff patient\ufeffmodel\ufefffor\ufeffdrug\ufeffdelivery,\ufeffhow\ufeffthis\ufeffmodel\ufeffvaries\ufeffwith\ufeffdifferent\ufeffsets\ufeffof\ufeffpharmacokinetic\ufeff(PK)\ufeff parameters.\ufeffThe\ufeffmodel\ufeffis\ufeffsimulated\ufeffthrough\ufeffa\ufeffMATLAB\ufeffSimulink\ufeffmodel,\ufeffresults\ufeffare\ufeffgiven\ufeffand\ufeffbest\ufeff models\ufeffin\ufefftargeting\ufeffthe\ufeffdrug\ufeffat\ufeffeffective\ufeffsite\ufeffcompartment\ufeffare\ufeffsuggested. International Journal of Reliable and Quality E-Healthcare Volume 8 • Issue 1 • January-March 2019