The diagnostic challenge of ptosis and diplopia: Cavernous sinus syndrome as the sole sign of unknown pancreatic cancer

Abstract

Cavernous sinus syndrome (CSS) is a rare condition that presents with clinical signs and symptoms due to the involvement of the cranial nerves (CN) III, IV, VI, V1, and V2. Various causes such as vascular, inflammatory, infectious, or neoplastic pathologies are involved in the etiology. CSS is rarely the first sign of cancer. In this report, we would like to describe a unique patient who manifested with CSS in which the etiological factor behind the clinic was a metastatic pancreatic adenocarcinoma previously unknown.