Validation of the Korean Version of the Patient-Reported Outcomes Measurement Information System 29 Profile V2.1 among Cancer Survivors.

Abstract

Purpose\nThe purpose of the study was to validate the Korean version of Patient-Reported Outcomes Measurement Information System 29 Profile V2.1 (K-PROMIS-29 V2.1) among cancer survivors.\n\n\nMaterials and Methods\nParticipants were recruited from outpatient clinics of the Comprehensive Cancer Center at the Samsung Medical Center in Seoul, South Korea, from September to October 2018. Participants completed a survey questionnaire that included the K-PROMIS-29 V2.1 and the European Organisation for Research and Treatment of Cancer Quality Of Life Core Questionnaire (EORTC QLQ-C30). Principal component analysis and confirmatory factor analysis (Principal Component Analysis, confirmatory factor analysis) and Pearson s correlations were used to evaluate the reliability and validity of the K-PROMIS-29 V2.1.\n\n\nResults\nThe mean age of the study participants was 54.4 years, the mean time since diagnosis was 1.2 (± 2.4) years, and 349 (87.3%) completed the entire questionnaire. The Cronbach s alpha coefficients of the seven domains in the K-PROMIS-29 V2.1 ranged from 0.81 to 0.96, indicating satisfactory internal consistency. In the CFA, the goodness-of-fit indices for the K-PROMIS-29 V2.1 were high (comparative fit index, 0.91 and standardized root-mean-squared residual, 0.06). High to moderate correlations were found between comparable subscales of the K-PROMIS-29 V2.1 and subscales of the EORTC QLQ-C30 (r=0.52-0.73).\n\n\nConclusion\nThe K-PROMIS-29 V2.1 is a reliable and valid measure for assessing the health-related quality of life domains in a cancer population, thus supporting their use in studies and oncology trials.