Association between Uric Acid and Metabolic Syndrome in Homozygous Sickle Cell Patients

Abstract

The objective of this study was to assess the association between uric \nacid and the metabolic syndrome and its \ncomponents in homozygous sickle cell patients. This is a prospective \ncase/control study of sickle cell SS patients. Each patient \nwas matched to a control of the same sex and age ± 2 years. In our framework, we used the criteria for defining metabolic syndrome according to \nInternational Diabetes Federation (IDF) 2009. Assay of all biological parameters was performed with the ARCHITECT ci4100, Abbot (Chicago, \nIllinois, USA). Data were collected with Excel 2016 software and statistical \nanalysis was done using XLSTAT 2019 software. Student’s T test was \nused to compare means and a p-value less \nthan 0.05 was considered significant. The study \npopulation consisted of 100 homozygous sickle cell patients with an average age \nof 26 years with a sex ratio of 0.58. The prevalence of metabolic syndrome in \nour population according to the IDF 2009 was 2%. In our study 28% of patients \npresented with hyperuricemia. Uricaemia was significantly elevated in patients \nwith components of the metabolic syndrome, in particular in 33% of patients \nwith a large waist circumference, in 25% of hypertensive patients, in 50% of \npatients with hypertriglyceridemia and in 60% of patients with hypertriglyceridemia \nand low HDL-cholesterol levels. Significant correlations were found between \nuricemia and certain components of the metabolic syndrome, in particular the \nlevel of triglycerides (r = 0.31, p = 0.002), blood sugar (r = 0.16; p = 0.012), \naround size (r = 0.071; p ≤ 0.05), HDL-Cholesterol (r = ﹣0.01; p = 0.018), PAS (r = 0.076; p = 0.035) and PAD (r = ﹣0.18; p = \n0.0015).