Journal of Tuberculosis Research | 2021
Diagnostic Value of TB-IGRA, PPD, TB-DNA-PCR and TB-Ab in Silicosis Complicated with Tuberculosis
Abstract
Purpose: The purpose of this article is to investigate the clinical value of TB-IGRA (Tuberculosis-Interferon Gamma Release Assay), \nPPD (Intradermal Terbuculin Test), TB-DNA-PCR \n(Tuberculosis-Deoxyribonucleic-Polymerase Chain Reaction) and TB-Ab (Tuberculosis-Antibody) \nin diagnosing silicosis complicated with pulmonary tuberculosis. Methods: 53 cases of suspected silicosis complicated with pulmonary tuberculosis were \nselected in the time span ranging from February 2017 to May 2019. TB-IGRA test, \nPPD test, TB-DNA-PCR and TB-Ab detection were performed. The sensitivity, specificity, \npositive predictive value and negative predictive value were calculated. Results: Silicosis and pulmonary tuberculosis were diagnosed in \n11 cases, with an incidence of 20.75%. The positive rates of TB-IGRA, PPD, TB-DNA-PCR \nand TB-Ab were 66.04%, 30.19%, 5.67% and 26.42%, respectively. The sensitivity was \n90.91%, 81.82%, 27.27% and 54.55% respectively. The specificity was 42.86%, 80.95%, \n100% and 80.95% respectively. The positive predictive values were 28.57%, 50%, 100% \nand 42.86% respectively. The negative predictive values were 94.44%, 91.89%, 84% \nand 87.18%. The positive rate, sensitivity and negative predictive value of TB-IGRA \nwere the highest, while the specificity of TB-DNA-PCR was the highest yet with low \npositive rate, sensitivity and positive predictive value. Conclusion: The positive rate and sensitivity of TB-IGRA were high, yet with poor specificity, \nso it was impossible to judge whether the cases belonged to active pulmonary tuberculosis. \nThe combination of PPD and TB-DNA-PCR could improve the sensitivity, specificity \nand positive predictive value, and the diagnostic accuracy of active pulmonary tuberculosis, \nwhich showed satisfactory clinical value.