Synthesis, X-ray analysis and antibacterial study of silver complex with ethyl-5-hydroxy- 2-oxo-2H-chromene-3-carboxylate

Abstract

ABSTRACT . A novel silver complex [Ag(C 12 H 9 O 5 ) 2 ] was synthesized by the reaction of silver salt (AgNO 3 )and coumarin based ligand (ethyl- 5 -hydroxy- 2 -oxo- 2H -Chromene- 3 -carboxylate) at room temperature. The synthesized complex was characterized by using different analytical techniques like melting point (mp), infrared (IR) spectroscopy, powder X-ray diffraction (PXRD), thermo gravimetric analysis (TGA), atomic absorption spectroscopy (AAS) and mass spectrometry (ESI-MS). Ligand showed activity with MIC 20 µg/mL, 15 µg/mL, 15 µg/mL for S. aurues , E. coli and S. typhi , respectively whereas MIC values of Ag-complex for above mentioned bacterial strains were found to be 15 µg/mL, 10 µg/mL, 10 µg/mL, respectively.\xa0 Ligand could not inhibit the growth of B. Subtilis , P. auruginosa , MRSA but Ag-complex showed MIC 30 µg/mL, 25 µg/mL for B. Subtilis and P. auruginosa . It also remained ineffective against MRSA. KEY WORDS : Silver complex, Ethyl- 5 -hydroxy- 2 -oxo- 2H -Chromene- 3 -carboxylate, Antibacterial study Bull. Chem. Soc. Ethiop. 2019 , 33(3), 467-474.\xa0 DOI: https://dx.doi.org/10.4314/bcse.v33i3.7