encephalitis | 2021
Low-dose interleukin-2 as a novel therapeutic option for refractory paraneoplastic neurologic syndrome: a case of chronic relapsing anti-Ma2/Ta paraneoplastic myeloradiculopathy
Abstract
Paraneoplastic neurologic syndromes (PNS) include several types of neurological disorders, such as cerebellar degeneration, limbic encephalitis, encephalomyelitis, and myelopathy [1]. Most cases of PNS are immune-mediated and are associated with onconeural antibodies [2]. In close association with specific cancers, several onconeural antibodies are known to cause PNS [3]. Unlike other autoimmune diseases, some cases of PNS are refractory to classical immunotherapy [4]. Herein, we present a case of paraneoplastic myeloradiculopathy with Ma2/Ta antibody that was successfully treated with low-dose interleukin-2 (IL-2). The patient recovered completely after low-dose IL-2 treatment, and other previously administered immunotherapies elicited only a partial or no therapeutic response. Low-dose interleukin-2 as a novel therapeutic option for refractory paraneoplastic neurologic syndrome: a case of chronic relapsing anti-Ma2/Ta paraneoplastic myeloradiculopathy Seon-Jae Ahn, Han-Sang Lee, Woo-Jin Lee, Kon Chu