A SAFETY EVALUATION AND TOLERABILITY OF ARTHOHILLS CAPSULE AN AYURVEDA FORMULATION IN OSTEOARTHRITIS SUBJECTS

Abstract

Background: Osteoarthritis (OA) also a similar clinical manifestation in Ayurveda as Sandhivata is a chronic degenerative disorder. Ayurveda medicine had very good potential for Osteoarthritis (OA) patients. Ayurveda would provide significantly better results comparatively than any medication in alternative medical streams. Objectives: The aim of the study was to evaluate the safety and tolerability of Arthohills capsule on total clinical fitness, hematological and X-ray parameters in osteoarthritis subjects assessed on VAS (Visual analogue scale) and WOMAC Osteoarthritis Index (Western Ontario and McMaster Universities). Materials and methods: It was an observational clinical study conducted on 30 subjects of Osteoarthritis (OA). 2 capsules of Arthohills capsules (500 mg) twice a day for 21 days were given to the 30 volunteers. The data was assessed on clinical symptoms, VAS and WOMAC score. Results: At baseline visit, on Visual Analogue Scale (VAS) assessed the average joint (knee) pain score was 40.28 ± 4.78. The average joint pain (knee) score (VAS) reduced significantly from 40.28 ± 4.78 to 34.77 after 7th day treatment with Arthohills Capsule. The mean total WOMAC score at the baseline visit was 48.21 ± 1.123 to 27.12 ± 2.142 after completion of the study which was reduced significantly. Thus all the parameters and clinical symptoms were reduced significantly from baseline to completion of the treatment in OA subjects (P<0.001). Conclusions: Arthohills capsule has been put to critical safety tests in Osteoarthritis subjects and found to be devoid of any adverse effects. It provides good clinical evidence to prove the efficacy and safety of Arthohills capsule in OA subjects.