GENETIC STUDY OF PSORIASIS DISEASE : A REVEIEW

Abstract

Psoriasis is a common inflammatory skin disease with an etiology based on both environmental and genetic factors .it may be caused by heritable predisposition who patients carry gene of psoriasis. The main genetic determinant for psoriasis known as –susceptibility1 (PSORS1) locus within the MHC on chromosome 6p21 (location of the HLA genes) is considered the major genetic determinant of psoriasis. In addition, linkage studies had identical 10 potential susceptibility loci several single nucleotide polymorphisms (SNP) in the receptor forinterleukin12 and 23(IL-12 and IL-23) had been linked to psoriasis and other chronic inflammatory conditions. In addition, the IL12B gene, which encodes the p40 subunit of IL-12 and IL-23, as well as the IL23A gene, which encodes the p19 subunit of IL-23, are strongly associated with psoriasis. This disease is triggered and worsened by some medications, infections, skin trauma, obesity, and stress, and those suffering from psoriasis are at higher risk for both cardiovascular disease and depression. It affects high range of people world wide, it is considered a public health problem. It has significant impacts on both physical and emotional health-related quality of life comparable to other major illnesses. The skin in psoriasis patches are typically red, dry, itchy, and scaly. Psoriasis varies in severity from small, localized patches to complete body coverage. Different methods have been used for psoriasis diagnosis with different sensitivity and specificity, some are conventional such as dermoscopy, biopsy, histopathology and molecular methods but it is typically based on the signs and symptoms. psoriasis is usually based on the appearance of the skin, The disease may begin at any age, the female infected more than male. Epidemiologic and basic scientific evidence contribution have led to the recognition of psoriasis as a disorder with important health implications that extend beyond the skin.