Archive | 2021
Vitamin D Associated Peculiarities in Women with Mild Covid-19 and Effect of Calcifediol on the Level of Vitamin D and Possibly, on Disease Outcome - Prospective Pilot Study
Abstract
Presented study provides information about prospective pilot study concerning the vitamin D \xa0in women with mild COVID-19 (SARSCoV2) and effect of Calci f ediol on the vitamin D level and possibly, on disease outcome. The study involved 30 women aged 48 to 72 years who were treated for a mild form of new coronavirus infection between 1.09.2020 - 1.12.2020 at the First University Clinic of TSMU. In all patients, the new type SARSCoV2 was confirmed by polymerase chain reaction performed with reagents-Xpert Xpress SARS-CoV-2 (Cepheid, USA) on GeneXpert (USA) analyzer (closed system). D-dimer, ferritin, C-reactive protein and lactate dehydrogenase were detected upon the hospital admission. Vitamin D was defined using Roche reagents (electrochemiluminescence method; Roche HITACHICobase-411 device- Switzerland). On the 1 st day of hospital admission, all patients received 0.266 mg (1 capsule) of calcifediol (16000 UI) in the form of the drug Hydroferol (FAES FARMA, S.A ., Spain ) . Vitamin D and -reactive protein was defined repeatedly on the 5 th day of treatment. Results: Studies have shown that on the 5 th day after hydroferol administration the vitamin D level in p atients with COVID-19 was significantly increased [16 . 8 (12 . 2–24 . 2) vs. 56 . 4 (52 . 3–62 . 2), p<0 . 0001]. Negative relation ship was found between the onset of symptoms and baseline vitamin D levels (F = 5.9223, p <0.026). The negative relationship was found between the repeatedly defined levels of vitamin D and C-reactive protein (F=12.82, p<0.009) also, pointing on the positive treatment effect of vitamin D on the course of mild form of Covid-19. None of the patients required continued treatment in the intensive care unit and were discharged home with satisfactory state. Conclusion: Vitamin D supposedly plays the important role in pathogenesis and outcome of SARSCoV2 virus infected patients. Additional large-scale randomized placebo-controlled studies on the role of vitamin D in COVID-19 pathogenesis are needed .