Anti-oxidant and Anti-inflammatory Effects of Cordyceps militaris Extracts

Abstract

This study investigated antioxidant and anti-inflammatory in order to confirm the possibility of functional materials that can improve skin diseases using Cordyceps militaris extracts. As a result of measuring the total polyphenol content in the solvent extract of Cordyceps sinensis extracted while decreasing the ethanol content, the content was high in 100% water, 30% ethanol, and 50% ethanol extract. As a result of measuring DPPH and ABTS free radical scavenging activities, it was confirmed that 100% water, 30% ethanol, and 50% ethanol extracts had superior antioxidant activity compared to other solvent extracts. In particular, in the case of 50% ethanol extract, it was confirmed that the antioxidant ability was excellent even at a low concentration compared to other extracts. As a result of confirming the efficacy of reducing skin inflammation against 50% ethanol extract using the HaCaT cell line, it was confirmed that the protein level of the CCL17 and CCL22 cytokine increased by TNF-αTNF-α/IFN-γ decreased by 77.8-81.5% and 61.9-67.4%, respectively. In conclusion, the 50% ethanol extract of Cordyceps militaris is likely to be used as a functional material related to skin diseases in the future.