Cerebellar liponeurocytoma in an elderly patient: DNA methylation profiling as a helpful diagnostic tool.

Abstract

AIM\nCerebellar liponeurocytoma is a rare primary cerebellar neoplasm that mostly occurs in adults, however, it is rare in the elderly.\n\n\nMATERIALS AND METHODS\nWe report, in a 79-year-old female, a recurrent vermian cerebellar mass that was previously diagnosed as primary cerebellar tumor with neuroendocrine differentiation. The recurrent lesion showed anaplastic features and lipidization.\n\n\nRESULTS\nDNA methylation profiling was performed for the recurrent tumor, which showed a high score match for cerebellar liponeurocytoma.\n\n\nCONCLUSION\nThis report confirms the usefulness of DNA methylation profiling for the diagnosis of challenging CNS tumors.