New hematological biomarkers in patients with atrial septal aneurysm

Abstract

Mean platelet volume/platelet count (MPV/PC) and monocyte/lymphocyte (MLR), neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratios are new hematological markers showing systemic platelet activation and inflammation. The aim of this study was to compare new hematological markers in patients with atrial septal aneurysm (ASA) and to determine their relationship in patients with ASA. 70 ASA and 47 healthy subjects (as control group) were included in the study. Demographic, clinical, echocardiographic and hematological values of the groups were recorded. MPV/PC ratio and MLR were significantly higher in ASA group compared to control group (0.03 ± 0.013 vs 0.02 ± 0.009, P=0.02 and 0.27 ± 0.15 vs 0.22 ± 0.08, P=0.03). NLR and PLR were not different between the groups. The presence of ASA was positively correlated with MLR and MPV/PC, left atrium, left ventricular (LV) septum thickness and LV posterior wall thickness, while red blood cell (RBC) was negatively correlated. However, in multivariate linear regression analysis, there was an independent relation between the presence of ASA and MPV/PC, MLR, LV septum thickness and RBC. We found that MPV/PC ratio and MLR from new hematological biomarkers are independent predictors for the presence of ASA.