The influence of antidepressants and actigraphy-derived sleep characteristics on pediatric multiple sleep latency testing.

Abstract

STUDY OBJECTIVES\nResearch evaluating the influence of rapid eye movement suppressing antidepressants (REMS-AD) on multiple sleep latency test (MSLT) results and the value of performing actigraphy prior to this test in children and adolescents is lacking. We examined the impact of REMS-AD and actigraphy parameters on mean sleep latency (MSL) and sleep-onset REM episodes (SOREMs) on MSLT in a pediatric clinical sample.\n\n\nMETHODS\nThis was a retrospective chart review at a quarternary referral center. We identified 164 MSLTs conducted in patients aged less than 18 years between 2014-2017. Correlations between REMS-AD, self-reported sleep duration, actigraphy parameters and each of the outcomes (MSL and SOREMs) were examined. Regression analyses accounting for clinical characteristics were performed.\n\n\nRESULTS\nMean age of the sample was 11.9±4.19 years, 62% were female, 28 (17%) were on REMS-AD (48% of whom were able to discontinue these medications prior to MSLT) and mean pediatric daytime sleepiness score was 21.7±6.1. MSL was 11.27±5.77 min and mean number of SOREMs 0.55±1.04. Patients on a REMS-AD at initial assessment had fewer SOREMs compared to those not taking these medications (0.17±0.19 versus 0.62±0.09; p=0.04); no difference was noted in MSL (10.36±1.10 versus 11.47±0.50; p=0.36). Increased time in bed on actigraphy (TIBa) correlated with a longer MSL and fewer SOREMs (r=0.23; p=0.04 and r=0.316; p=0.004 respectively). Following regression analyses, use of REMS-AD continued to remain associated with fewer SOREMs; greater TIBa, but not self-reported sleep duration, was associated with a longer MSL (all p<0.05).\n\n\nCONCLUSIONS\nClinicians should account for the use of REMS-AD and utilize actigraphy to determine time in bed while interpreting the results of a pediatric MSLT.