ALK Positive Anaplastic Large Cell Lymphoma of Oral Cavity: A Case Report

Abstract

Introduction: Anaplastic lymphoma kinase-positive (ALK+) anaplastic large cell lymphoma is a rare subtype of non-Hodgkin lymphomas, which is usually presented as a systemic advanced stage disease. Extranodal involvement is common in skin, bone, soft tissue, lung and liver. Primary presentation in oral cavity is extremely rare. Case Presentation: Here, a 28-year-old man with gingival swelling in the left mandibular molar area after tooth extraction and regional lymphadenopathy is reported. Microscopic examination revealed anaplastic large lymphoid cells with the positive expression of ALK protein. Conclusions: Although the overall survival of ALK-positive anaplastic large cell lymphoma is better than other types of T-cell lymphomas, it is not clear for its oral counterparts.