Oral Hyperpigmented Macules Observed during Endoscopy Intubation.

Abstract

1 A 73-year-old woman visited our hospital for endoscopic resection of a gastric adenoma measuring approximately 1.2 cm. She had no history of smoking or intake of medications such as tetracycline or chemotherapeutic agents that might be associated with mucocutaneous pigmentation. She had undergone a colonoscopy 2 years ago that revealed several tiny polyps, which were histopathologically diagnosed as lowgrade tubular adenoma. Multiple hyperpigmented macules were observed on the tongue and buccal mucosa when introducing the endoscope into her oral cavity for gastric adenoma resection (Fig. 1A). Endoscopic submucosal dissection was successfully performed, and the final pathologic diagnosis was low-grade dysplasia. A detailed history after the procedure revealed that the dark macules had existed for 10 years on the inner aspect of her lower lip (Fig. 1B), and these macules had been consistently increasing in number. Dermoscopy of the labial lesions revealed a brownish reticular pattern along with granules (Fig. 1C). Longitudinal brownish-black streaks were also observed on the left second fingernail and right thumbnail (Fig. 1D). There was no itching or pain associated with BRIEF REPORT