Annals of Internal Medicine | 2021
A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated
Abstract
Continued follow-up of participants in COVID-19 vaccine trials after vaccination of the placebo group permits determination of vaccine durability and allows the incorporation of a booster trial if waning vaccine efficacy is observed, while ensuring the ethical treatment of participants.