Increased Prevalence of Renal Diseases, Metabolic Syndrome and Fragmented Germ Cells with Reduced Endogenous Estrogen and Androgen: A Brief Study

Abstract

Background: 20th 21st centuries after implementation of contraception, abortion, witnessed unexplained increased prevalence of renal diseases. \nObjectives: Altruistic correlation of increase in prevalence of renal diseases – metabolic syndrome, with implemented contraception as probable etiology, [if any] is sought after. \nMethods: In 2012, retrospective analysis of, prevalence of renal diseases in 350 patients of 20-35 years, 35-50 years, >50 years age groups, from data collected by convenient, stratified random sampling, from different geographical locations, between 2003-2012 and its association with presence, absence of contraception, abortion was undertaken including many variables; simultaneously, serum estrogen levels obtained from 105 patients, was also analyzed.1989-2012 clinical practice detected 403 patients with varied diseases after consumption of fish without scales, gills of which 97 patients had nephritis and they were also analyzed for correlation with status of contraception. \nResults: Contraception was associated with 2.5-4 fold increase in renal diseases among 20-50 years [p 50 years age group [p 50 years [p <0.0005]. \nConclusion: Concept is contraception results in smashed, agonizing fragmentation of germ cells, the germ cells not being permitted to traverse the normal path, with negative feed back to the hypothalamic pituitary axis and resultant decreased endogenous estrogen or androgen resulting in defaulted genomic repertoire, deranged cell metabolism, cell cycle resulting in increased degeneration with consequent atrophy, sclerosis, metabolic syndrome; fragmented germ cells are recognized as foreign, leading to autoimmunity with resultant inflammation, fibrosis resulting in this 275% increased prevalence of diseases including renal pathology; after hysterectomy, orchidectomy 500% increase in prevalence of diseases is observed. \nContraception reversal declined the diseases, consequent to restored normal path traversal of germ cells, return of hormones by 79.9% [of corresponding normal for age] as a cause and effect phenomenon.