Ana Isabel Oliveira
Instituto Politécnico Nacional
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Featured researches published by Ana Isabel Oliveira.
Frontiers in Plant Science | 2016
Ana Isabel Oliveira; Cláudia Pinho; Bruno Sarmento; Alberto Carlos Pires Dias
Hypericum perforatum is a perennial plant, with worldwide distribution, commonly known as St. John’s wort. It has been used for centuries in traditional medicine for the treatment of several disorders, such as minor burns, anxiety, and mild to moderate depression. In the past years, its antidepressant properties have been extensively studied. Despite that, other H. perforatum biological activities, as its neuroprotective properties have also been evaluated. The present review aims to provide a comprehensive summary of the main biologically active compounds of H. perforatum, as for its chemistry, pharmacological activities, drug interactions and adverse reactions and gather scattered information about its neuroprotective abilities. As for this, it has been demonstrated that H. perforatum extracts and several of its major molecular components have the ability to protect against toxic insults, either directly, through neuroprotective mechanisms, or indirectly, through is antioxidant properties. H. perforatum has therefore the potential to become an effective neuroprotective therapeutic agent, despite further studies that need to be carried out.
Food Research International | 2018
Francisca Rodrigues; Teresa Moreira; Diana Pinto; Filipa B. Pimentel; Anabela S.G. Costa; M. Antónia Nunes; T.G. Albuquerque; Helena S. Costaa; Ana Palmeira-de-Oliveira; Ana Isabel Oliveira; Stefania Sut; Stefano Dall'Acqua; M. Beatriz P.P. Oliveira
The nutritional composition of Calluna vulgaris flowers as well as the phytochemical profile, antioxidant (DPPH and FRAP assays), antimicrobial and cytotoxic (in human immortalized non-tumorigenic keratinocyte and fibroblasts) activities of aqueous, hydroalcoholic and ethanolic extracts were evaluated. A high content of fiber and carbohydrates (75%) and the prevalence of α-tocopherol as vitamer deserves attention. Linolenic (35%), linoleic (27%) and palmitic (21%) acids were the most abundant fatty acids. Qualitative and quantitative analysis by LC-MS and 1NMR indicated high levels of quercetin, kaempferol and myricetin derivatives as well as procyanidins. The hydro-alcoholic extract displayed the highest antioxidant activity and total phenolics (TPC) and flavonoid contents (TFC). No adverse effects on cells were observed until a concentration of 100 μg/mL and a good antimicrobial activity was reported against S. epidermidis and S. aureus with the hydro-alcoholic extract. The data obtained demonstrated that wild plants like heather, although not being a common nutritional reference, can be used in an alimentary base as a source of bioactive compounds, namely antioxidants.
International Journal of Biological Macromolecules | 2017
Ana Isabel Oliveira; Cláudia Pinho; Pedro Fonte; Bruno Sarmento; Alberto Carlos Pires Dias
Quercetin and biapigenin are antioxidant and neuroprotective compounds present in Hypericum perforatum, with potential application in neurodegenerative diseases. Quercetin has shown to have excellent antioxidant activities. Biapigenin possesses a distinctive mechanism of action, preventing the onset of calcium deregulation and mitochondrial dysfunction. The main aim of this study was to establish a new delivery system encapsulating H. perforatum neuroprotective fraction, isolated from it,containing quercetin and biapigenin into poly(Ɛ-caprolactone) (PCL) nanoparticles. It also aimed to study its hepatoprotective potential. Different formulation parameters were optimized, resulting in a stable formulation of polymer:compounds ratio 1:0.1 with a mean particle size of 185nm, zeta potential around -20mV and association efficiency close to 100%. Compounds in vitro release, under physiological conditions, showed an initial burst followed by a sustained release. The antioxidant functional properties of these compounds were not altered by encapsulation. PCL-loaded nanoparticles protected HepG2 cells from intrinsic compound toxicity at high concentrations. Depending on the incubation regimen, quercetin-biapigenin PCL-loaded nanoparticles or free compounds were more effective in protecting HepG2 cells against tert-butylhydroperoxide-induced toxicity. This is the first report of the encapsulation of a quercetin-biapigenin mixture in a polymeric matrix, specifically, in PCL, with synergic anti-oxidant and hepatoprotective effects.
VIII Colóquio de Farmácia - Farmacoeconomia e Gestão do Medicamento | 2012
Agostinho Cruz; Agostinho Cunha; Ana Isabel Oliveira; Ângelo Jesus; Cláudia Pinho; Marlene Santos; Patrícia Correia; Rita Ferraz Oliveira
Planta Medica | 2014
Rosário Oliveira; L Barreiro; A Cruz; Ana Isabel Oliveira; Alberto Carlos Pires Dias; Cláudia Pinho; S Fernandes; Nm Santos; J Morgado
Planta Medica | 2014
Cláudia Pinho; Ana Isabel Oliveira; N Paraíso; Ana Carvalho; Cristovao F. Lima; Alberto Carlos Pires Dias
Planta Medica | 2014
Ana Isabel Oliveira; Cláudia Pinho; Bruno Sarmento; Alberto Carlos Pires Dias
IX Colóquio de Farmácia - Envelhecimento e Saúde | 2013
Agostinho Cruz; Agostinho Cunha; Ana Isabel Oliveira; Ângelo Jesus; Cláudia Pinho; Marlene Santos; Patrícia Correia; Rita Ferraz Oliveira
Archive | 2012
Ângelo Jesus; Rita Ferraz Oliveira; Cátia Martins; Ana Isabel Oliveira; Cláudia Pinho; Marlene Santos; Patrícia Correia; Agostinho Cunha; Agostinho Cruz
I Congresso Internacional da Saúde Gaia-Porto | 2010
Cláudia Pinho; Patrícia Correia; Agostinho Cunha; Ângelo Jesus; Ana Isabel Oliveira; Rita Ferraz Oliveira; Marlene Santos; Agostinho Cruz