Angela Nurini Agni
Gadjah Mada University
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Featured researches published by Angela Nurini Agni.
Ophthalmic Epidemiology | 2017
Muhammad Bayu Sasongko; Angela Nurini Agni; Firman S. Wardhana; Satya P. Kotha; Prateek Gupta; Tri Wahyu Widayanti; Supanji; Felicia Widyaputri; Rifa Widyaningrum; Tien Yin Wong; Ryo Kawasaki; Jie Jin Wang; Suhardjo Pawiroranu
ABSTRACT Purpose: There are no available data about diabetic retinopathy (DR) in the Indonesian population. This report summarizes the rationale and study design of the Jogjakarta Eye Diabetic Study in the Community (JOGED.COM), a community-based study to estimate the prevalence and risk factors of DR in persons with type 2 diabetes in Jogjakarta, Indonesia. Methods: The JOGED.COM aimed to examine a cross-sectional sample of 1200 persons with type 2 diabetes aged 30 years and older residing in the study area. We identified 121 community health centers (CHCs) in Jogjakarta and listed 35 CHCs with non-communicable diseases facilities. Multi-stage, clustered random sampling was used to select 22 CHCs randomly. We included CHCs with coverage population >30,000, and excluded those classified as 100% rural. Lists of persons with diabetes confirmed by their family physician were provided from each CHC. Examinations procedures included detailed interviews, general and eye examinations, anthropometry and body composition scan, and dilated fundus photography. Results: We collaborated with local health authorities, family physicians, and local health practitioners in the recruitment phase. A total of 1435 invitations were distributed, and 1184 people (82.5%) with type 2 diabetes participated in this study, of whom 1138 (79.3%) had completed data with gradable retinal images. Conclusions: JOGED.COM is the first epidemiologic study of DR in an Indonesian population. This study will provide key information about the prevalence and risk factors of DR in the community. These data are very important for future health promotion programs to reduce the burden of DR in the population.
American Journal of Ophthalmology | 2017
Muhammad Bayu Sasongko; Felicia Widyaputri; Angela Nurini Agni; Firman S. Wardhana; Satyaprabha Kotha; Prateek Gupta; Tri Wahyu Widayanti; Supanji Haryanto; Rifa Widyaningrum; Tien Yin Wong; Ryo Kawasaki; Jie Jin Wang
PURPOSE To report the prevalence of diabetic retinopathy (DR) and DR-related blindness in an Indonesian population with type 2 diabetes. METHODS Design: Population-based cross-sectional study. SETTING Community health centers. STUDY POPULATION We recruited 1184 people aged older than 30 years with type 2 diabetes residing in Jogjakarta, Indonesia. Multistage, clustered random sampling based on regencies and districts in Jogjakarta was used. OBSERVATION PROCEDURE Detailed interviews, general and eye examinations, and anthropometric measurement were performed. Disc- and macula-centered retinal photographs were taken to assess DR. The definition of DR followed a modified Airlie House classification system and was categorized into mild, moderate, and vision-threatening DR (VTDR). MAIN OUTCOME MEASURE(S) Prevalence and severity of DR. RESULTS The median (range) age and diabetes duration of participants was 59 (52-65) and 4 (2-9) years. The prevalence of DR was 43.1% (95% confidence interval 39.6%-46.6%), with mild, moderate, and severe NPDR and PDR to be 9.41%, 7.46%, 11.1%, and 12.1%, respectively. The prevalence of VTDR was 26.3% (23.1%-29.5%). Longer diabetes duration, higher fasting glucose, presence of hypertension, and foot ulcers were associated with DR and VTDR. The prevalence of bilateral blindness was 4% and 7.7% in persons with DR and VTDR. CONCLUSIONS This study reports a high prevalence of any DR and VTDR among Indonesian adults with type 2 diabetes in urban and rural areas: approximately 1 in 4 adults with diabetes had VTDR and 1 in 12 of those with VTDR was bilaterally blind, suggesting the need for appropriate screening and management of DR among the Indonesian population.
Ophthalmic Epidemiology | 2018
D.P Dharmastuti; Angela Nurini Agni; Felicia Widyaputri; Suhardjo Pawiroranu; Z.M Sofro; Firman S. Wardhana; S Haryanto; Tri Wahyu Widayanti; S Kotha; Prateek Gupta; Muhammad Bayu Sasongko
ABSTRACT Purpose: To investigate the association of physical activity (PA) and sedentary behaviour with diabetic retinopathy (DR) in type 2 diabetes adults. Methods: A community-based cross-sectional study of adults with type 2 diabetes. DR was assessed from disc- and macula-centred fundus photograph, and categorised into mild, moderate non-proliferative DR (NPDR), and Vision-Threatening DR (VTDR). Worse eye was used to determine the person’s DR severity. PA was assessed using WHO Global Physical Activity Questionnaire (GPAQ). All of the PA components, including daily sitting time, walking distance, sleeping duration, and exercise were converted based on the physical activity ratio and then calculated to obtain the mean physical activity level (PAL). The mean PAL was then classified into sedentary, moderate, and vigorous lifestyle. Results: There were 1116 participants, 43.1% with any DR and 26.3% VTDR. The prevalence of DR/VTDR in sedentary, moderate, and vigorous physical activity group was 41.9%/22.7%, 39.2%/23.9%, and 32.7%/20.4% respectively. A longer duration of daily sedentary lifestyle (>3 hours) was significantly associated with presence of DR (OR 1.66; 95% CI 1.17–2.35; p < 0.01) and VTDR (OR 1.74; 1.16–2.62; p < 0.01). These associations remained significant after adjusting for age, gender, duration of diabetes, systolic blood pressure and physical activity. There was no significant association between sleeping duration, walking distance, and vigorous activity and DR. Conclusions: In this study, prolonged daily sedentary activity was strongly associated with VTDR. This finding suggests that public health campaign for reducing daily sedentary activities in individuals with type 2 diabetes may offer benefit to reduce the burden of DR and VTDR.
Diabetes Care | 2018
Muhammad Bayu Sasongko; Felicia Widyaputri; Dian Caturini Sulistyoningrum; Firman S. Wardhana; Tri Wahyu Widayanti; Supanji Supanji; Rifa Widyaningrum; Sarah R. Indrayanti; Idhayu A. Widhasari; Angela Nurini Agni
OBJECTIVE To investigate the associations of estimated resting metabolic rate (RMR), body fat (BF), subcutaneous fat (SCF), visceral fat (VF), fat-free mass (FFM) percentage, BMI, and waist circumference (WC) with diabetic retinopathy (DR) in Indonesian adults with type 2 diabetes. RESEARCH DESIGN AND METHODS This was a community-based cross-sectional study of 1,184 subjects with type 2 diabetes. DR was assessed from fundus photography and categorized as mild, moderate nonproliferative DR (NPDR), and vision-threatening DR (VTDR). RMR and body composition parameters were measured using automated body composition scan. Logistic regression with semipartial correlation analysis was used. RESULTS DR and VTDR were present in 43.1 and 26.3% of participants, respectively. After adjustment for age, sex, diabetes duration, fasting glucose, systolic blood pressure, smoking, diabetic ulcer, and use of combined diabetes treatment, per SD increase in RMR (odds ratio [OR] 2.60 [95% CI 2.19–3.07]; P < 0.001) was associated with DR, while per SD increases in BF (0.66 [95% CI 0.56–0.78]; P < 0.001), FFM (0.69 [0.57–0.84]; P < 0.001), VF (0.77 [0.67–0.88]; P < 0.001), BMI (0.83 [0.73–0.94]; P = 0.004), and WC (0.81 [0.73–0.91]; P < 0.001) were inversely associated with presence of DR. Similar associations were found for VTDR. Among all variables, RMR had the largest contribution to the variance in the DR model (39%). CONCLUSIONS In this study, RMR and body composition measures were strongly associated with and contributed considerably to the presence and severity of DR. These findings, if confirmed, suggest that RMR and body composition may be strong markers that represent actual metabolic state in the pathophysiology of DR.
Journal of Glaucoma | 2018
Rossada Adiarti; Retno Ekantini; Angela Nurini Agni; Tien Yin Wong; Muhammad Bayu Sasongko
International Journal of Ophthalmology | 2018
Marzarendra Dhion Erlangga; Indra Tri Mahayana; Jajah Fachiroh; Angela Nurini Agni; Agus Supartoto; Suhardjo Pawiroranu
Ophthalmologica Indonesiana | 2016
Widyandana Widyandana; Angela Nurini Agni; Agus Supartoto; Suhardjo Suhardjo
Ophthalmologica Indonesiana | 2016
Widya Prafitri Rasmiyati; Suhardjo Suhardjo; Angela Nurini Agni
Jurnal Oftalmologi Indonesia | 2010
Sri Yuliani Elida; Agus Supartoto; Angela Nurini Agni
Jurnal Oftalmologi Indonesia | 2008
Andi Rachmi Patompo; Angela Nurini Agni; Tri Wahyu Widayanti