Hui Wang
Chinese Academy of Sciences
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Publication
Featured researches published by Hui Wang.
Nature Communications | 2014
Jiechao Ge; Minhuan Lan; Bingjiang Zhou; Weimin Liu; Liang Guo; Hui Wang; Qingyan Jia; Guangle Niu; Xing Huang; Hangyue Zhou; Xiang-Min Meng; Pengfei Wang; Chun-Sing Lee; Wenjun Zhang; Xiaodong Han
Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (1O2) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce 1O2 via a multistate sensitization process, resulting in a quantum yield of ~1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of 1O2 quantum yield, water dispersibility, photo- and pH-stability, and biocompatibility.
Advanced Materials | 2014
Hui Wang; Lisha Xie; Qian Peng; Lingqiang Meng; Ying Wang; Yuanping Yi; Pengfei Wang
Thermally activated delayed fluorescence emitters with small energy gap between the triplet and singlet (ΔEST ), TXO-PhCz and TXO-TPA, have been successfully synthesized by combining a hole-transporting TPA/PhCz moiety and an electron-transporting TXO moiety. Both compounds display efficient solid-state luminescence with an efficient up-conversion of the triplet to singlet. OLEDs based on them exhibt high performance up to 21.5%, which is among the best reported for OLEDs.
Journal of the American Chemical Society | 2013
Hui Wang; Tao Jiang; Ming-Hua Xu
New, simple, sulfinamide-based branched olefin ligands have been developed and successfully used in Rh-catalyzed asymmetric arylations of cyclic ketimines, providing efficient and highly enantioselective access to valuable benzosultams and benzosulfamidates containing a stereogenic quaternary carbon center. This is the first example of applying a sulfur-olefin ligand in catalytic asymmetric addition of imines.
Bioresource Technology | 2013
Tianzhong Liu; Junfeng Wang; Qiang Hu; Pengfei Cheng; Bei Ji; Jinli Liu; Yu Chen; Wei Zhang; Xiaoling Chen; Lin Chen; Lili Gao; Chunli Ji; Hui Wang
The potential of microalgae biofuel has not been realized because of low productivity and high costs associated with the current cultivation systems. In this paper, an attached cultivation method was introduced, in which microalgae cells grew on the surface of vertical artificial supporting material to form algal film. Multiple of the algal films were assembled in an array fashion to dilute solar irradiation to facilitate high photosynthetic efficiency. Results showed that a broad range of microalgae species can grow with this attached method. A biomass productivity of 50-80 g m(-2) d(-1) was obtained outdoors for Scenedesmus obliquus, corresponding to the photosynthetic efficiency of 5.2-8.3% (total solar radiation). This attached method also offers lots of possible advantages over traditional open ponds, such as on water saving, harvesting, contamination controlling and scale-up. The attached cultivation represents a promising technology for economically viable production of microalgae biofuels.
Nature | 2016
Liangshu Zhong; Fei Yu; Yunlei An; Yonghui Zhao; Yuhan Sun; Zhengjia Li; Tiejun Lin; Yanjun Lin; Xingzhen Qi; Yuanyuan Dai; Lin Gu; Jin-Song Hu; Shifeng Jin; Qun Shen; Hui Wang
Lower olefins—generally referring to ethylene, propylene and butylene—are basic carbon-based building blocks that are widely used in the chemical industry, and are traditionally produced through thermal or catalytic cracking of a range of hydrocarbon feedstocks, such as naphtha, gas oil, condensates and light alkanes. With the rapid depletion of the limited petroleum reserves that serve as the source of these hydrocarbons, there is an urgent need for processes that can produce lower olefins from alternative feedstocks. The ‘Fischer–Tropsch to olefins’ (FTO) process has long offered a way of producing lower olefins directly from syngas—a mixture of hydrogen and carbon monoxide that is readily derived from coal, biomass and natural gas. But the hydrocarbons obtained with the FTO process typically follow the so-called Anderson–Schulz–Flory distribution, which is characterized by a maximum C2–C4 hydrocarbon fraction of about 56.7 per cent and an undesired methane fraction of about 29.2 per cent (refs 1, 10, 11, 12). Here we show that, under mild reaction conditions, cobalt carbide quadrangular nanoprisms catalyse the FTO conversion of syngas with high selectivity for the production of lower olefins (constituting around 60.8 per cent of the carbon products), while generating little methane (about 5.0 per cent), with the ratio of desired unsaturated hydrocarbons to less valuable saturated hydrocarbons amongst the C2–C4 products being as high as 30. Detailed catalyst characterization during the initial reaction stage and theoretical calculations indicate that preferentially exposed {101} and {020} facets play a pivotal role during syngas conversion, in that they favour olefin production and inhibit methane formation, and thereby render cobalt carbide nanoprisms a promising new catalyst system for directly converting syngas into lower olefins.
Nano Letters | 2010
Huan Chen; Hui Wang; Xiaohong Zhang; Chun-Sing Lee; Shuit-Tong Lee
Silicon nanowires (SiNWs) having curved structures may have unique advantages in device fabrication. However, no methods are available to prepare curved SiNWs controllably. In this work, we report the preparation of three types of single-crystal SiNWs with various turning angles via metal-assisted chemical etching using (111)-oriented silicon wafers near room temperature. The zigzag SiNWs are single crystals and can be p- or n-doped using corresponding Si wafer as substrate. The controlled growth direction is attributed to the preferred movement of Ag nanoparticles along 001 and other directions in Si wafer. Our results demonstrate that metal-assisted chemical etching may be a viable approach to fabricate SiNWs with desired turning angles by utilizing the various crystalline directions in a Si wafer.
Gut | 2017
Xiaoguang Li; Wenbo Yao; Ya Yuan; Peizhan Chen; Bin Li; Jingquan Li; Ruiai Chu; Haiyun Song; Dong Xie; Xiaoqing Jiang; Hui Wang
Objective Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited effective treatment options. An alternative strategy is to target cells, such as tumour-infiltrating macrophages, in the HCC tumour microenvironment. The CCL2/CCR2 axis is required for recruitment of monocytes/macrophages and is implicated in various aspects of liver pathology, including HCC. We investigated the feasibility of CCL2/CCR2 as a therapeutic target against HCC. Design CCL2 expression was analysed in two independent HCC cohorts. Growth of three murine HCC cells was evaluated in an orthotopic model, a postsurgical recurrence model and a subcutaneous model in mice after blocking CCL2/CCR2 axis by a novel CCR2 antagonist or knocking out of host CCR2. In vivo macrophage or T cell depletion and in vitro cell coculture were further conducted to investigate CCL2/CCR2-mediated crosstalk between tumour-associated macrophages (TAMs) and tumour cells. Result CCL2 is overexpressed in human liver cancers and is prognostic for patients with HCC. Blockade of CCL2/CCR2 signalling with knockout of CCR2 or with a CCR2 antagonist inhibits malignant growth and metastasis, reduces postsurgical recurrence, and enhances survival. Further, therapeutic blocking of the CCL2/CCR2 axis inhibits the recruitment of inflammatory monocytes, infiltration and M2-polarisation of TAMs, resulting in reversal of the immunosuppression status of the tumour microenvironment and activation of an antitumorous CD8+ T cell response. Conclusions In patients with liver cancer, CCL2 is highly expressed and is a prognostic factor. Blockade of CCL2/CCR2 signalling suppresses murine liver tumour growth via activating T cell antitumour immune response. The results demonstrate the translational potential of CCL2/CCR2 blockade for treatment of HCCs.
Green Chemistry | 2009
Hui Wang; Zengxi Li; Yanqing Liu; Xiangping Zhang; Suojiang Zhang
The degradation of poly(ethylene terephthalate) (PET) was successfully achieved using ionic liquids. The products were separated according to their solubilities in boiling water. Average molecular weights of the main product were determined by gel permeation chromatography (GPC). The physicochemical properties of the product have been characterized by scanning electron microscopy equipped with an energy dispersive X-ray analyzer (SEM/EDX), X-ray diffractometer, infrared spectrometric analyzer, differential scanning calorimeter, and thermogravimetric analysis instrument. The influences of experimental parameters, such as the reaction time, reaction temperature, and addition of different catalysts on the solubility of PET were investigated. A study on the recycling of the ionic liquid shows that ionic liquid could be used repeatedly. Moreover, the solubility of PET in the recycled ionic liquid is higher than that in fresh ionic liquid. Further study shows that the increase of solubility in the recycled ionic liquid is attributable to the presence of a minor amount of water. A mechanism of the degradation of PET in 1-butyl-3-methylimidazolium chloride ([bmim]Cl) was proposed. In addition, the kinetics of this reaction was investigated. Results show that this degradation process is a first-order kinetic reaction and the activation energy is 232.79 kJ mol−1.
Kidney International | 2008
Ying Xiao; M. Ge; Xiang Xue; Cheng Wang; Hui Wang; Xiongfei Wu; Laifeng Li; L. Liu; Xinming Qi; Yun hai Zhang; Yingrui Li; H. Luo; T. Xie; Jun Gu; Jin Ren
Cytochrome P450s metabolize the naturally occurring nephrotoxin aristolochic acid. Using liver-specific cytochrome P450 reductase-null mice we found that a low but lethal dose of aristolochic acid I was ineffective in wild-type mice. Induction of hepatic CYP1A by 3-methylcholanthrene pretreatment markedly increased the survival rate of wild type mice given higher doses and these mice were protected from aristolochic acid I-induced renal injury. Clearance of aristolochic acid I in null mice was slower compared to control and the 3-methylcholanthrene-pretreated wild type mice. The levels of aristolochic acid I in the kidney and liver were much higher in null mice but much lower in 3-methylcholanthrene-treated compared to control wild type mice. Hepatic microsomes from 3-methylcholanthrene-treated wild type mice had greater activity compared to untreated mice. Finally, aristolochic acid I was more cytotoxic than its major metabolite aristolactam I and this cytotoxicity was decreased in human renal tubular epithelial HK2 cells in the presence of a reconstituted hepatic microsome-cytosol (S9) system. These results indicate that hepatic P450s play an important role in metabolizing aristolochic acid I into less toxic metabolites and thus have a detoxification role in aristolochic acid I-induced kidney injury.
Nature Chemistry | 2017
Peng Gao; Shenggang Li; Xianni Bu; Shanshan Dang; Ziyu Liu; Hui Wang; Liangshu Zhong; Minghuang Qiu; Chengguang Yang; Jun Cai; Wei Wei; Yuhan Sun
Although considerable progress has been made in carbon dioxide (CO2) hydrogenation to various C1 chemicals, it is still a great challenge to synthesize value-added products with two or more carbons, such as gasoline, directly from CO2 because of the extreme inertness of CO2 and a high C–C coupling barrier. Here we present a bifunctional catalyst composed of reducible indium oxides (In2O3) and zeolites that yields a high selectivity to gasoline-range hydrocarbons (78.6%) with a very low methane selectivity (1%). The oxygen vacancies on the In2O3 surfaces activate CO2 and hydrogen to form methanol, and C−C coupling subsequently occurs inside zeolite pores to produce gasoline-range hydrocarbons with a high octane number. The proximity of these two components plays a crucial role in suppressing the undesired reverse water gas shift reaction and giving a high selectivity for gasoline-range hydrocarbons. Moreover, the pellet catalyst exhibits a much better performance during an industry-relevant test, which suggests promising prospects for industrial applications. It is still a great challenge to synthesize value-added products with two or more carbons directly from CO2. Now, a bifunctional catalyst composed of reducible metal oxides (In2O3) and zeolites (HZSM-5) is prepared and yields high selectivity to gasoline-range hydrocarbons (78.6%) with a high octane number directly from CO2 hydrogenation.