Mesbah Shams
Shiraz University of Medical Sciences
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Featured researches published by Mesbah Shams.
Journal of Diabetes | 2016
Mojtaba Heydari; Kaynoosh Homayouni; Mohammad Hashem Hashempur; Mesbah Shams
The aim of the present study was to examine the safety and efficacy of a topical formulation of Citrullus colocynthis in patients with painful diabetic polyneuropathy (PDPN).
Journal of Integrative Medicine | 2018
Zahra Hajmohammadi; Mojtaba Heydari; Majid Nimrouzi; Pouya Faridi; Mohammad Javad Zibaeenezhad; Gholamhossein Ranjbar Omrani; Mesbah Shams
BACKGROUND Lipid-lowering effect of Rhus coriaria L. (Rhus) has been investigated in multiple animal studies with promising results. Nonetheless, its clinical efficacy has not been adequately examined. OBJECTIVE The aim of this study was to evaluate the lipid-lowering effects of Rhus among patients with hyperlipidemia. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS The study was designed as a two-arm, double-blind placebo-controlled randomized clinical trial, using a parallel design. Eighty patients with primary hyperlipidemia were randomly assigned to receive Rhus capsules or placebo for 6 weeks. MAIN OUTCOME MEASURES The serum lipid levels, apolipoprotein-A1 (Apo-A1) and apolipoprotein-B (Apo-B) were measured. RESULTS Mean serum high-density lipoprotein cholesterol (HDL-C) and Apo-A1 levels were significantly increased in the Rhus group, compared with the placebo group, after 6 weeks of intervention (P = 0.001). The analysis of covariance test including age, gender, body mass index (BMI), and smoking as co-variables revealed that the increase in HDL-C and Apo-A1 levels remained significant, and increases in HDL-C were dependent on the increase in Apo-A1 levels. No significant difference was observed between Rhus and placebo groups in terms of mean reductions in total cholesterol, low-density lipoprotein cholesterol and triglyceride levels; however, more significant improvement was observed among obese patients (BMI ≥ 30 kg/m2). CONCLUSION The study showed significant increases in HDL-C and Apo-A1 levels in response to Rhus supplementation in patients with hyperlipidemia. TRIAL REGISTRATION ClinicalTrials.gov ID: NCT02295293.
Journal of Evidence-Based Complementary & Alternative Medicine | 2016
Massih Sedigh-Rahimabadi; Mohammadmehdi Fani; Mahsa Rostami-chijan; Mohammad M. Zarshenas; Mesbah Shams
This study evaluates the safety and efficacy of Punica granatum var pleniflora mouthwash in treatment of diabetic gingivitis. In a double-blind randomized clinical trial 80 patients with diabetes mellitus and gingivitis were assigned to Golnaar and chlorhexidine 0.2% groups. After using mouthwashes for 2 weeks; participants underwent tooth scaling and the last visit was 2 weeks after scaling. The primary outcome measures were plaque, modified gingival and gingival bleeding indices, and pocket depth. Both interventions had significant improvement on all of the gingival and plaque indices (P < .001 for all indices). There were no significant differences between Golnaar and chlorhexidine in primary outcome measures except for modified gingival index for which Golnaar mouthwash had a superiority after 2 weeks when comparing with chlorhexidine (P = .039). Meanwhile, Golnaar mouthwash had no staining effect. Golnaar mouthwash is safe and effective in treatment of gingivitis in diabetic patients although further studies are recommended.
Iranian Red Crescent Medical Journal | 2013
Mohammad Ali Nazarinia; Mesbah Shams; Eskandar Kamali Sarvestani; Saeede Shenavande; Maryam Khademalhosseini; Zeinab Khademalhosseini
Background Systemic Sclerosis (SSc) is a systemic connective tissue disease. In this study, we compared the serum Homocystein (Hcy) level between patients with SSc and normal control group. Objectives The current study was conducted to determine whether serum Hcy levels are elevated in SSc patients and whether there is any correlation between Hcy levels and RP, Gastro intestinal and lung involvement. Patients and Methods Forty one patients who fulfilled the diagnostic criteria for SSc (39 females and 5 males) and Forty four community-based healthy individuals (sex and age matched) were enrolled in to the study. Serum Hcy, vitamin B12, and folate levels were determined. Results Thirty three patients (70.45%) had GI involvement, twenty two patients (50%) had lung involvement and twenty seven patients (61.36%) had Raynaud’s phenomena. Mean serum Hcy level in control group was 22.78 ± 6.018 μmol/L and in case group was 19.43 ± 7.205 μmol/L, shows that the serum Hcy level in control group was significantly higher than patients (P = 0.020). Conclusions Serum Hcy level is significantly lower in SSc patients than in control group. There is no statistically significant correlation between serum Hcy level and organ involvements.
Journal of Evidence-Based Complementary & Alternative Medicine | 2017
Massih Sedigh-Rahimabadi; Mohammadmehdi Fani; Mahsa Rostami-chijan; Mohammad M. Zarshenas; Mesbah Shams
This study evaluates the safety and efficacy of Punica granatum var pleniflora mouthwash in treatment of diabetic gingivitis. In a double-blind randomized clinical trial 80 patients with diabetes mellitus and gingivitis were assigned to Golnaar and chlorhexidine 0.2% groups. After using mouthwashes for 2 weeks; participants underwent tooth scaling and the last visit was 2 weeks after scaling. The primary outcome measures were plaque, modified gingival and gingival bleeding indices, and pocket depth. Both interventions had significant improvement on all of the gingival and plaque indices (P < .001 for all indices). There were no significant differences between Golnaar and chlorhexidine in primary outcome measures except for modified gingival index for which Golnaar mouthwash had a superiority after 2 weeks when comparing with chlorhexidine (P = .039). Meanwhile, Golnaar mouthwash had no staining effect. Golnaar mouthwash is safe and effective in treatment of gingivitis in diabetic patients although further studies are recommended.
Iranian Red Crescent Medical Journal | 2015
Nakisa Rasaei; Mesbah Shams; Eskandar Kamali-Sarvestani; Mohammad Ali Nazarinia
Background: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease caused by immune system-mediated tissue damage. Autoimmune thyroiditis (AT) is an organ-specific disease associated with production of a variety of antibodies such as antinuclear antibodies, anti-double-stranded DNA, anti-Ro antibodies and anti-cardiolipin antibodies. Objectives: The aim of this study was to evaluate the prevalence of thyroid dysfunction and thyroid auto-antibodies in patients with SLE and its relation to SLE disease and other autoantibodies. Patients and Methods: This was a case-control study. The study included a total of 88 patients with SLE and 88 age- and sex-matched healthy volunteers as control group. Two study groups were compared regarding thyroid function test, antinuclear antibody (ANA), antibodies to double-stranded DNA (dsDNA), anti- thyroglobulin antibody (anti-Tg), and anti-thyroid peroxidase (anti-TPO) antibody. Results: The mean age of SLE patients and controls were 32.16 ± 9.19 and 32.48 ± 9.47 years, respectively (P = 0.821). Patients had significantly higher prevalence (43.2% vs. 23.9%; P = 0.015) and titers (221.8 ± 570.5 vs. 78.2 ± 277.2; P = 0.036) of antibodies to Tg compared to controls. The patients had significantly lower titers of T3 compared to controls (125.2 ± 35.6 vs. 136.2 ± 26.5; P = 0.021). The titers of T4, TSH and anti-TPO antibody did not differ significantly between the two study groups. Conclusions: Thyroid dysfunction was not higher in SLE patients compared to healthy individuals. However, anti-Tg antibodies were higher in SLE patients. It has not yet been established that thyroid function tests should be performed routinely in SLE patients.
International journal of research in ayurveda and pharmacy | 2014
Mojtaba Heydari; Kaynoosh Homayouni; Mohammad Hashem Hashempur; Mesbah Shams
Topi cal Citrullus colocynthis formulations are used as botanical treatment for painful diabetic neuropathy in Asian countries . This pilot study aimed to evaluat e the safety and efficacy of topical formulation of Citrullus colocynthis fruit extract in treatment of painful diabetic neuropathy. The study was designed as a prospective interventional case series . Eight adults with clinical diagnosis of painful diabetic neuropathy confirmed by electrodiagnosis received oil - based topical formulation of Citrullus coloc ynthis fruit extract twice daily for three months. The patients were evaluated before and after the intervention in terms of Neuropathic Pain Scale, Electrodiagnostic findings and reported adverse reactio ns after three months. Mean neuropathic pain scores reduced significantly three months after the intervention. Significant small size improvements were documented in some of electrodiagnostic findings. No local or systemic adverse effects were reported. More studies with randomized placebo - controlled design are recommended for meticulous evaluation of the effects of topical Citrullus colocynthis in treatment of painful diabetic neuropathy .
Education and Health | 2012
Mojtaba Heydari; Mohammad Hashem Hashempur; Mesbah Shams
which means there is no need for students to know, for the importance of its treatment. The guidelines also suggest that at least 70% of curriculum time and examinations should be devoted to topics with an “A” grade of importance. After dividing our school’s summed curriculum time and exam questions into these four disease entity classes of importance, we compared their distribution against the recommended emphasis each class should receive according to the national guidelines, specifically 70% for topics of level “A” importance and 30% for all others, less important topics combined. The concordance between the recommended time split and the split within our curriculum was evaluated with a Chi-square test. Results are summarized in Figure 1. We found significant differences (P<0.01) between the proportion of our school’s curricular time spent on clinical topics in “A” versus “B”
Current Rheumatology Reviews | 2018
Asghar Zare; Mohammad Ali Nazarinia; Mesbah Shams; Mohammad Javad Fallahi
BACKGROUND Systemic sclerosis is a disorder of connective tissue with unknown cause, affecting the skin and internal organs, characterized by fibrotic changes. OBJECTIVE To determine the correlation between serum homocysteine level and interstitial lung involvement in systemic sclerosis. MATERIALS AND METHODS In this case - control study, 59 patients who fulfilled the ACR/EULAR classification criteria for systemic sclerosis and were referred to Hafez Hospital of Shiraz, Iran, were included as the case group. Fifty nine healthy subjects were involved as the control group. Patients were divided into two groups based on interstitial lung involvement and two subtypes, diffuse and limited type. Serum homocysteine, vitamin B12, and folate levels compared between the controls, and cases groups. RESULTS Of 59 case and control group, 53 (%89.8) were female and the mean age did not differ in both groups (P=0.929). Thirty five (%59.3) patients had interstitial lung involvement and 38(%64.4) had diffuse cutaneous systemic sclerosis. The mean serum homocysteine level was 13.9±6.3 µmol/L in the case and 13.7±9.2 µmol/L in the control group (P=0.86). The mean serum homocysteine level did not differ between the patients with and without interstitial lung involvement (P=0.52). The patients with lung involvement was older than those without lung involvement (P=0.004). Lung disease was more common in diffuse type (P=0.014). CONCLUSION In our study, serum homocysteine level did not differ between the patients and healthy subjects. Also, there was no correlation between serum homocysteine level and lung involvement, but lung involvement was more common in older patients and also diffuse subtype.
Complementary Therapies in Medicine | 2018
Nasrindokht Zamani; Mesbah Shams; Majid Nimrouzi; Mohammad M. Zarshenas; Amin Abolhasani Foroughi; Ebrahim Fallahzadeh Abarghooei; Mohammad Reza Fattahi
OBJECTIVE The aim of the study is to evaluate the effects of Zataria multiflora Boiss. (Shirazi thyme) (ZM) supplementation on nonalcoholic fatty liver disease (NAFLD) and related insulin resistance (IR). DESIGN In this randomized double-blind placebo-controlled clinical trial, 85 patients with NAFLD were administered either 700 mg ZM powder or placebo twice daily for 12 weeks. All patients were advised to follow the recommendations for diet modification. RESULTS ZM supplementation resulted in a significant reduction in serum insulin level (-2.72 ± 0.80 vs -0.67 ± 0.90, P=0.030), insulin resistance (-0.80 ± 0.22 vs 0.06 ± 0.22, P=0.023), systolic (-3.44 ± 1.05 vs 1.03 ± 0.98, P= 0.002) and diastolic (-2.33 ± 0.77 vs 0.26 ± 0.63, P= 0.009) blood pressure in patients with NAFLD in comparison with the placebo group. There was no significant difference between two groups regarding serum levels of alanine aminotransferase (ALT), high sensitive C-reactive protein (hs-CRP), Tumor necrosis factor-α (TNF-α), grade of fatty liver in ultrasonography, lipid profiles, and other outcomes. CONCLUSION ZM supplementation with daily dose of 1400 mg for 12 weeks improved insulin resistance in patients with NAFLD. Further studies with longer duration and larger sample size are recommended.