P. Yasuda
University of Southern California
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Featured researches published by P. Yasuda.
Diabetes Care | 2011
Barbara J. Anderson; Sharon L. Edelstein; Natalie Walders Abramson; Lorraine E. Levitt Katz; P. Yasuda; S. Lavietes; Paula M. Trief; S. Tollefsen; Siripoom V. McKay; Patricia Kringas; T. Casey; Marsha D. Marcus
OBJECTIVE The study objective was to examine the prevalence of depressive symptoms and relationships to quality of life and demographics in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study’s large, ethnically diverse youth with type 2 diabetes. RESEARCH DESIGN AND METHODS A total of 704 youth with type 2 diabetes <2 years’ duration, aged 10–17 years, and BMI ≥85th percentile completed depressive symptoms and quality of life measures. RESULTS Some 14.8% reported clinically significant depressive symptoms, and older girls had significantly higher rates than older boys. CONCLUSIONS Rates of significant depressive symptoms were similar to those of healthy adolescents and lower than those of teens with type 1 diabetes. Elevated depressive symptoms, particularly in older girls, suggest clinicians assess vulnerability.
The Journal of Pediatrics | 2014
Natalie Walders-Abramson; Elizabeth M. Venditti; Carolyn E. Ievers-Landis; Barbara J. Anderson; Laure El ghormli; Mitchell E. Geffner; J. Kaplan; Michaela B. Koontz; R. Saletsky; Marissa Payan; P. Yasuda
OBJECTIVE To examine the relationships between stressful life events and physiological measures, adherence to prescribed oral medication regimens, depressive symptoms, and impaired quality of life (QoL) in adolescents with recent-onset type 2 diabetes (T2D). STUDY DESIGN Data were collected from 497 ethnically diverse participants (66% female) in the final year of the Treatment Options for Type 2 Diabetes in Adolescents and Youth multicenter clinical trial. Exposure to 32 possible events over the previous year and rating of subsequent distress were collected by self-report and summarized as a major stressors score. This score was analyzed for relationship to glycemic control (hemoglobin A1c and treatment failure), body mass index, diagnosis of hypertension or triglyceride dyslipidemia, adherence to a prescribed oral medication regimen, presence of depressive symptoms, and impaired QoL. RESULTS The total number of major stressful life events in the adolescents with T2D was calculated, with 33% reporting none, 67% reporting ≥ 1, 47% reporting ≥ 2, 33% reporting ≥ 3, and 20% reporting ≥ 4. There were no associations between the major stressors score and physiological measures or diagnosis of comorbidities. The odds of medication nonadherence increased significantly from those reporting ≥ 1 major stressor (OR, 1.58; P = .0265) to those reporting ≥ 4 major stressors (OR, 2.70; P = .0009). Significant odds of elevated depressive symptoms and impaired QoL were also found with increased reporting of major stressors. CONCLUSION Exposure to major stressful life events is associated with lower adherence to prescribed oral medication regimens and impaired psychosocial functioning in adolescents with T2D.
Pediatric Diabetes | 2018
Robert I. Berkowitz; Marsha D. Marcus; Barbara J. Anderson; Linda M. Delahanty; N. Grover; Andrea M. Kriska; Lori Laffel; A. Syme; Elizabeth M. Venditti; Dorothy J. Van Buren; Denise E. Wilfley; P. Yasuda; Kathryn Hirst
To assess the association of proxies of behavioral adherence to the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) lifestyle program with changes in glycemic control and obesity in a multi‐ethnic sample of youth with type 2 diabetes.
The Journal of Pediatrics | 2015
Carolyn E. Ievers-Landis; Natalie Walders-Abramson; Nancy Amodei; Kimberly L. Drews; J. Kaplan; Lorraine E. Levitt Katz; S. Lavietes; R. Saletsky; D. Seidman; P. Yasuda
OBJECTIVES To characterize, during a 2-year period, the proportion of youth with type 2 diabetes (T2D) enrolled in the Treatment Options for Type 2 Diabetes in Adolescents and Youth study that reported ever at least trying smoking cigarettes and/or drinking alcohol. STUDY DESIGN Longitudinal data were examined for participants with T2D ages 10-18 years at baseline. Youth psychosocial, parent/family, environmental, and biological correlates of trying health risk behaviors were tested via cross-sectional multivariate models at each time point. Longitudinal models were explored for selected factors. RESULTS Data were obtained from the Treatment Options for Type 2 Diabetes in Adolescents and Youth studys ethnically diverse participants at baseline (N=644), 6-month (N=616), and 24-month (N=543) assessments. The percentage of youth ever trying only smoking remained stable at 4%; only drinking alcohol increased from 17% to 26%, and both smoking and drinking increased from 10% to 18% during the 2-year period. Factors related to trying health risk behaviors were older age, male sex, non-Hispanic white race-ethnicity, lower grades, more depressive symptoms, and stressful life events. Depressive symptoms, stressful life events, and body mass index Z-score (the latter with smoking only) were related to engagement in health risk behaviors over time. CONCLUSIONS Youth with T2D who are already at risk for health complications and who reported engaging in activities that further increase the likelihood of life-threatening morbidities were characterized. Although most correlates of trying these risk behaviors are nonmodifiable, intervention efforts may need to focus on potentially modifiable factors, such as depressive symptoms and lower grades.
Diabetes Care | 2015
Ruth S. Weinstock; Paula M. Trief; Laure El ghormli; Robin Goland; Siripoom V. McKay; Kerry Milaszewski; Jeff Preske; Steven M. Willi; P. Yasuda
OBJECTIVE This study examined parental factors associated with outcomes of youth in the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial. RESEARCH DESIGN AND METHODS Of 699 youth with type 2 diabetes in the TODAY cohort, 623 (89.1%) had a parent participate and provide data at baseline, including weight, HbA1c, blood pressure, symptoms of depression, binge eating (BE), and medical history. Youth were followed 2–6.5 years. Data were analyzed using regression models and survival curve methods. RESULTS Parental diabetes (43.6% of parents) was associated with higher baseline HbA1c (P < 0.0001) and failure of youths to maintain glycemic control on study treatment (53.6% vs. 38.2% failure rate among those without a diabetic parent, P = 0.0002). Parental hypertension (40.6% of parents) was associated with hypertension in youth during TODAY (40.4% vs. 27.4% of youth with and without parental hypertension had hypertension, P = 0.0008) and with higher youth baseline BMI z scores (P = 0.0038). Parents had a mean baseline BMI of 33.6 kg/m2. Parental obesity (BMI >30 kg/m2) was associated with higher baseline BMI z scores in the youth (P < 0.0001). Depressive symptoms in parents (20.6% of parents) were related to youth depressive symptoms at baseline only (P = 0.0430); subclinical BE in parents was related to the presence of subclinical BE (P = 0.0354) and depressive symptoms (P = 0.0326) in youth throughout the study period. CONCLUSIONS Parental diabetes and hypertension were associated with lack of glycemic control, hypertension, and higher BMI z scores in youth. Further research is needed to better understand and address parental biological and behavioral factors to improve youth health outcomes.
Pediatric Diabetes | 2018
Andrea M. Kriska; Laure El ghormli; Kenneth C. Copeland; Janine A. Higgins; Carolyn E. Ievers-Landis; Lorraine E. Levitt Katz; Paula M. Trief; A. Wauters; P. Yasuda; Linda M. Delahanty
Little is known about the feasibility and impact of lifestyle intervention, determined by change in diet and cardiovascular fitness (CRF), on glycemic control in youth who are overweight with type 2 diabetes. This was examined in the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial cohort from across 15 US centers.
Diabetes Research and Clinical Practice | 2018
Dorothy J. Van Buren; Denise E. Wilfley; Marsha D. Marcus; Barbara J. Anderson; Natalie Walders Abramson; Berkowitz Rj; Carolyn E. Ievers-Landis; Paula M. Trief; P. Yasuda; Kathryn Hirst
The relationship between depressive symptoms and glycemic control in youth with type 2 diabetes was assessed at baseline (n = 682), 6, and/or 24 months (n = 576). Neither baseline nor persistence of depressive symptoms was significantly associated with maintenance of glycemic control. Nevertheless, depressive symptoms were common, suggesting the importance of repeated screening.
Diabetes management | 2015
Mary E. Larkin; Natalie Walders-Abramson; Kathryn Hirst; Joyce Keady; Carolyn E. Ievers-Landis; Elizabeth M. Venditti; P. Yasuda
Diabetes Research and Clinical Practice | 2018
Elizabeth M. Venditti; K. Tan; N. Chang; Lori Laffel; G. McGinley; N. Miranda; J.B. Tryggestad; Natalie Walders-Abramson; P. Yasuda; Linda M. Delahanty