Yuling Xiao
Sichuan University
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Featured researches published by Yuling Xiao.
Respirology | 2010
Yonggang Zhang; Jie Zhang; Jin Huang; Xia Li; He C; Can Tian; Chunhong Peng; Liang Guo; Yuling Xiao; Hong Fan
Background and objective: Polymorphisms in the transforming growth factor‐β1 (TGF‐β1) gene have been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. A meta‐analysis was performed to investigate the association between polymorphisms in the TGF‐β1 gene and asthma susceptibility.
Respirology | 2010
Yonggang Zhang; Jie Zhang; Jin Huang; Xiaobo Li; Chao He; Can Tian; Chunhong Peng; Liang Guo; Yuling Xiao; Hong Fan
Background and objective: Polymorphisms in the transforming growth factor‐β1 (TGF‐β1) gene have been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. A meta‐analysis was performed to investigate the association between polymorphisms in the TGF‐β1 gene and asthma susceptibility.
Archives of Medical Research | 2010
Yonggang Zhang; Jin Huang; Jie Zhang; Xiaobo Li; Chao He; Yuling Xiao; Can Tian; Hua Wan; Yuliang Zhao; Yangzom-Ghising Tsewang; Hong Fan
BACKGROUND AND AIMS RANTES is a chemokine that assists the recruitment of inflammatory cells including eosinophils. Previous studies revealed that polymorphisms of RANTES were implicated in susceptibility to asthma, but a large number of studies reported apparently conflicting results. We performed a meta-analysis to investigate the association of these polymorphisms and asthma risk. METHODS Literature-based meta-analysis was supplemented by tabular data from investigation of all relevant studies regarding all polymorphisms of RANTES available before November 30, 2009, with investigation on potential sources of heterogeneity. RESULTS Ten case/control studies were included in the meta-analysis, involving a total of 1706 cases and 1685 controls. In a combined analysis, no significant associations with asthma risk were found on these two polymorphisms (-403G/A and -28C/G) without any publication bias. For the -403G/A polymorphism, in subgroup analysis by ethnicity, no significant associations were found in Asians, Europeans or African-Americans; in subgroup analysis by age, no significant associations were found in adults or children. In subgroup analysis by atopic status, the -403G/A polymorphism was significantly associated with asthma risk in atopic asthma (dominant model [OR = 1.38, 95% CI = 1.09-1.76, p = 0.009; P(het) = 0.10]; A vs. G model [OR = 1.25, 95% CI = 1.04-1.51, p = 0.02; P(het) = 0.11] and AG vs. GG model [OR = 1.37, 95% CI = 1.06-1.77, p = 0.02; P(het) = 0.14]). CONCLUSIONS This meta-analysis suggested that RANTES gene -403G/A polymorphism would be a risk factor among atopic asthma patients. To further evaluate gene-to-gene and gene-to-environment interactions on RANTES polymorphisms and asthma risk, more studies with thousands of patients are required.
Journal of the Neurological Sciences | 2011
Yonggang Zhang; Jie Zhang; Can Tian; Yuling Xiao; Xiaobo Li; Chao He; Jin Huang; Hong Fan
BACKGROUND The -1082G/A polymorphism in IL-10 gene has been extensively investigated for association to Alzheimers disease (AD), however, results of different studies have been inconsistent. The objective of this study is to assess the relationship of IL-10 -1082G/A polymorphism and AD risk by using meta-analysis. METHODS All eligible case-control studies were searched in Pubmed and Embase. Odds ratios (OR) with the 95% confidence intervals (CI) were used to assess the association. RESULTS A total of 2158 cases and 2088 controls in 12 case-control studies were included. The results indicated that the A allele carriers (AA+AG) had a 27% increased risk of AD, when compared with the homozygote GG (OR=1.27, 95%CI=1.02-1.58 for AA+AG vs. GG). In the subgroup analysis by ethnicity, significant elevated risks were associated with A allele carriers in Europeans (OR=1.27 and 95%CI=1.01-1.59 for AA+AG vs. GG), but not in Asians (OR=1.37 and 95%CI=0.32-5.88 for AA+AG vs. GG). CONCLUSIONS This meta-analysis suggested that the -1082G/A polymorphism of IL-10 gene would be a risk factor for AD. To further evaluate gene-to-gene and gene-to-environmental interactions between polymorphisms of IL-10 gene and AD risk, more studies with large groups of patients are required.
Respiratory Research | 2010
Xiaobo Li; Yonggang Zhang; Jie Zhang; Yuling Xiao; Jin Huang; Can Tian; Chao He; Yao Deng; Yingying Yang; Hong Fan
BackgroundPublished data regarding the associations between genetic variants and asthma risk in Chinese population were inconclusive. The aim of this study was to investigate asthma susceptible genes in Chinese population.MethodsThe authors conducted 18 meta-analyzes for 18 polymorphisms in 13 genes from eighty-two publications.ResultsSeven polymorphisms were found being associated with risk of asthma, namely: A Disintegrin and Metalloprotease 33 (ADAM33) T1-C/T (odds ratio [OR] = 6.07, 95% confidence interval [CI]: 2.69-13.73), Angiotensin-Converting Enzyme (ACE) D/I (OR = 3.85, 95%CI: 2.49-5.94), High-affinity IgE receptor β chain (FcεRIβ) -6843G/A (OR = 1.49, 95%CI: 1.01-2.22), Interleukin 13(IL-13) -1923C/T (OR = 2.99, 95%CI: 2.12-4.24), IL-13 -2044A/G (OR = 1.49, 95%CI: 1.07-2.08), Regulated upon Activation, Normal T cell Expressed and Secreted (RANTES) -28C/G (OR = 1.64, 95%CI: 1.09-2.46), Tumor Necrosis Factor-α (TNF-α) -308G/A(OR = 1.42, 95%CI: 1.09, 1.85). After subgroup analysis by age, the ACE D/I, β2-Adrenergic Receptor (β2-AR) -79G/C, TNF-α -308G/A, Interleukin 4 receptor(IL-4R) -1902G/A and IL-13 -1923C/T polymorphisms were found significantly associated with asthma risk in Chinese children. In addition, the ACE D/I, FcεRIβ -6843G/A, TNF-α -308G/A, IL-13 -1923C/T and IL-13 -2044A/G polymorphisms were associated with asthma risk in Chinese adults.ConclusionADAM33, FcεRIβ, RANTES, TNF-α, ACE, β2-AR, IL-4R and IL-13 genes could be proposed as asthma susceptible genes in Chinese population. Given the limited number of studies, more data are required to validate these associations.
Journal of Clinical Immunology | 2011
Yonggang Zhang; Jie Zhang; Can Tian; Yuling Xiao; Chao He; Xiaobo Li; Amrit Bogati; Jin Huang; Hong Fan
BackgroundThe −308 G/A polymorphism in TNF-α gene has been extensively investigated for association to asthma; however, results of different studies have been inconsistent. The aim of this study is to comprehensively evaluate the genetic risk of −308 G/A polymorphism in TNF-α gene for asthma.MethodsA meta-analysis was carried out to analyze the association between the −308 G/A polymorphism TNF-α gene and asthma risk.ResultsA total of 4717 cases and 5012 controls in 29 case–control studies were included in this meta-analysis. The result indicated that the variant A allele carriers had a 38% increased risk of asthma, when compared with the homozygote GG (odds ratio (OR) = 1.40, 95% confidence interval (CI), 1.13–1.68 for AA + AG vs. GG). In the subgroup analysis by ethnicity, significant elevated risks were associated with A allele carriers in Asians (OR = 1.53, 95% CI = 1.17–2.01 and P = 0.002) but not in Caucasians(OR = 1.06, 95% CI = 0.75–1.50 and P = 0.73). In the subgroup analysis by age, significant elevated risks were associated with A allele carriers in adults (OR = 1.44, 95% CI = 1.14–1.81, and P = 0.002) and children (OR = 1.37, 95% CI = 1.03–1.82, and P = 0.003). In the subgroup analysis by atopic status, significant elevated risks of asthma were associated with A allele carriers in atopic population (OR = 1.68, 95% CI = 1.34–2.10, and P < 0.00001) but not in non-atopic population (OR = 0.98, 95% CI = 0.58–1.68, and P = 0.95).ConclusionsOur results suggest that the TNF-α −308 G/A polymorphism contributes to susceptibility to asthma.
Journal of Medical Microbiology | 2011
Chao He; Yi Xie; Lei Zhang; Mei Kang; Chuanmin Tao; Zhixing Chen; Xiaojun Lu; Liang Guo; Yuling Xiao; Lina Duo; Hong Fan
The antibiotic susceptibility of Acinetobacter calcoaceticus-Acinetobacter baumannii complex strains recovered from the intensive care unit (ICU) of West China Hospital, Sichuan, PR China, from 2006 to 2009 was investigated. The identification of A. baumannii and analysis of carbapenemase-encoding genes and their relationship with ISAba1 were performed by PCR. Furthermore, a DiversiLab repetitive extragenic palindromic sequence-based PCR (rep-PCR) microbial typing system and a multilocus sequence typing (MLST) scheme were applied to assess the genetic relationship of the isolates. The results showed that the antibiotic susceptibility of the A. calcoaceticus-A. baumannii complex isolates changed and imipenem resistance increased rapidly between 2006 and 2009. The blaOXA-51-like and ISAba1-associated blaOXA-23 genes were prevalent in the imipenem-resistant A. baumannii isolates. However, the blaOXA-58-like gene was found in only one isolate and no metallo-β-lactamase genes were detected. The representative multidrug-resistant A. baumannii isolates were identified as one cluster by rep-PCR fingerprinting and belonged to the clonal complex 92 (CC92) according to MLST. These findings indicate a situation of increasing resistance and wide distribution of class D β-lactamase genes, especially the acquired ISAba1-associated blaOXA-23 gene, in A. baumannii isolates in the ICU of West China Hospital, probably caused by expansion of the CC92 clone.
Mycoses | 2015
Si‐Ying Wu; Yao Lei; Mei Kang; Yuling Xiao; Zhixing Chen
Previous reports on the molecular characteristics of clinical isolates of Cryptococcus species in China have focused on isolates from southeast China. To obtain a more detailed molecular epidemiology, a total of 92 cryptococcal isolates were collected from Sichuan province. A total of 24 isolates from 12 other provinces were collected for comparative study. Genotypes and mating types of 116 Cryptococcus isolates were determined. Among the 116 isolates, 43 isolates (19 isolates from Sichuan and 24 isolates outside of Sichuan) were analysed by multi‐locus sequence typing (MLST). All 116 clinical isolates were mating type α. Most isolates (114/116) were molecular type VNI and the remaining two isolates were VGI and VGII respectively. MLST results revealed five sequence types (STs) of C. neoformans including two novel STs, with most isolates identified as ST5. The two C. gattii isolates identified in our study were ST44 and ST159. Based on our report and previous studies, there are 15 C. neoformans STs in China which can be divided into three subgroups. The C. gattii isolate from Sichuan could be a scattered subtype of VGII (ST44). Our findings demonstrated that C. neoformans isolates in Sichuan are genetically homogeneous, and ST5 is the epidemic clone of C. neoformans in China.
BMC Microbiology | 2015
Limei Luo; Lijuan Wu; Yuling Xiao; Dan Zhao; Zhixing Chen; Mei Kang; Qi Zhang; Yi Xie
BackgroundQuorum Sensing (QS) systems influence biofilm formation, an important virulence factor related to the bacterial survival and antibiotic resistance. In Acinetobacter baumannii, biofilm formation depends on pili biosynthesis, structures assembled via the csuA/BABCDE chaperone-usher secretion system. QS signaling molecules are hypothesized to affect pili formation; however, the mechanism behind this remains unclear. This study aimed to demonstrate the possible role of QS signaling molecules in regulating pili formation and mediating the ability to form biofilms on abiotic surfaces.ResultsReal-time quantitative PCR analysis showed the expression of the csuA/BABCDE genes distinctly increased when co-cultured with C6-HSL (P < 0.05). Under the same experimental conditions, expression of BfmS and BfmR was significantly higher than the control strain (P < 0.05). A subsurface twitching assay showed a switch from a small to a large and structured clone that may result from enhanced twitching motility (P < 0.05). Transmission electron microscopy analysis of cells lifted from a MH broth co-cultured with C6-HSL showed more abundant pili-like structures than the control strain. We then tested the idea that the addition of a QS signal, and therefore induction of chaperone-usher secretion system genes, provides a greater benefit at higher biofilm densities. An assay for the total fluorescence intensity of the biofilm using Confocal Laser Scanning Microscopy revealed an obvious increase.ConclusionOur study demonstrated that, increased transcription of the BfmS and BfmR genes, QS signaling molecules enhance the expression of the chaperone-usher secretion system, and this expression is required for twitching motility in A. baumannii. The concomitant pili expression and strain twitching allowed A. baumannii to attach easily to abiotic surfaces and form biofilms at an earlier timepoint.
Labmedicine | 2013
Yuling Xiao; Mei Kang; Yi Tang; Zhiyong Zong; Yonggang Zhang; Chao He; Yao Deng; Hong Fan; Yi Xie
Kodamaea ohmeri ( K ohmeri ) is an emerging opportunistic fungal pathogen that infects an increasing number of immunocompromised patients worldwide. Herein, we present 3 cases of K ohmeri infection in mainland China: 1 case of peritonitis and 2 of fungemia. We review the 32 cases described thus far in the English-language medical literature to investigate the characteristics and treatment of K ohmeri infections and to compare the new cases with those described previously. The increase in infections highlights the significance of K ohmeri as a potential yeast pathogen. Early identification and appropriate antifungal therapy, combined with removal of implanted medical devices, greatly influence clinical outcomes. Further studies are required to determine optimal antifungal regimens and to obtain more comprehensive data on the use of novel antifungal agents such as voriconazole and echinocandins. * HIV : human immunodeficiency virus; CAPD : continuous ambulatory peritoneal dialysis; bpm : beats per minute; RBC : red blood cell; HGB : hemoglobin; WBC : white blood cell; PLT : platelet; ip : intraperitoneal; tid : 3 times a day; qn : once a night; iv : intravenously; qd : once a day; bid : twice a day; tiw : three times a week; HBV : hepatitis B virus; CT : computed tomography; q8h : once every 8 hours; q12h : once every 12 hours; ALB : plasma albumin; SCR : serum creatinine; CysC : serum cystatin C; BUN : blood urea nitrogen; AST : serum aspartate aminotransferase; PT : prothrombin time; APTT : activated partial thromboplastin time; PCT : serum procalcitonin; MODS : multiple organ dysfunction syndrome; ICU : intensive care unit; CRRT : continuous renal replacement therapy; CVC : central venous catheter; SDA : Sabouraud dextrose agar; ITS : internal transcribed spacer; PCR : polymerase chain reaction; BLAST : Basic Local Alignment Search Tool; MIC : minimum inhibitory concentration; CLSI : Clinical and Laboratory Standards Institute; MICs : minimum inhibitory concentrations