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Who is the culprit of red fever? Discover the secret hidden in genes!
Red fever, also known as Mitchell's disease, is a rare form of perivascular pain that usually affects blood vessels in the lower limbs or hands. The disease is characterized by frequent blockage of blood vessels, followed by burning sensation, redness, and inflammation of the skin. Patients face many challenges in their lives due to a wide range of triggers, such as heat, pressure, light activity, insomnia or stress.
“This kind of pain often makes patients feel so powerless that they feel troubled in their daily lives.”
Red fever can be divided into primary and secondary forms. The former is mainly caused by sodium channel mutations in the SCN9A gene. This discovery has changed our understanding of chronic neuropathic pain. According to research in 2004, the association between the SCN9A gene and red fever was confirmed for the first time. This achievement made red fever the first disease related to ion channel mutations.
Primary red fever can be divided into familial or sporadic types based on inheritance. The familial type is usually transmitted in an autosomal dominant inheritance manner. According to new research, several mutant forms play an important role in patients' pain perception.
"The pathogenesis of primary red fever is related to excessive enhancement of sodium channel function."
In clinical practice, patients often face uncomfortable symptoms, and these severe burning sensations and skin redness can affect their quality of life. Symptoms include erythema, swelling, and deep-seated pain, which are often accompanied by mood swings and occur at varying times.
According to another survey, red fever attacks mostly occur at night, interfering with patients' sleep quality. This forces patients to readjust their lifestyles to reduce the occurrence of triggers.
“Many patients have to avoid wearing shoes or socks because the heat from their feet can worsen the condition.”
Why is red fever prevalent in certain areas of southern China, especially rural areas? Studies have pointed out that an epidemic in Hubei Province in 1987 was closely related to upper respiratory tract infections. 60.6% of patients had a history of common colds before the onset of red fever.
The cause of red fever is not yet fully understood. But in some patients, researchers are uncovering potential links between the virus and the disease, which may change our understanding of the underlying cause.
In terms of treatment, for secondary red fever, the most effective method is to treat the underlying primary disease. But with primary red fever, understanding and avoiding triggers is the first step, and medication is another possible option.
“Patients’ suffering often leaves them feeling isolated and helpless, and we urgently need more in-depth research into this condition.”
As research progresses, new treatment options and research methods are emerging, however many patients still face a lengthy diagnosis process and painful symptom management. The scientific community's in-depth exploration of the genetic mutations of red fever may provide new hope for future treatments.
So, can we unravel the mystery of red fever through more in-depth genetic research and bring real hope for treatment to patients?
