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Why is GFR a key indicator of kidney health? Uncover the secret behind filtration rate!
The kidneys are important organs for maintaining human health and are responsible for a variety of functions, including regulating acid-base balance, maintaining fluid balance, removing toxic substances, and synthesizing a variety of hormones. However, these complex functions rely on the filtering capacity of the kidneys, which is what is assessed by the renal tubular filtration rate (GFR). GFR is widely regarded as a key indicator of kidney health because it directly reflects the functional status of the kidneys.
GFR is an important indicator of renal tubular filtration, and its changes are often early warning signs of kidney disease.
The renal tubular filtration rate (GFR) describes the amount of plasma filtered through the renal tubules per minute and can be measured and estimated using different methods. Clinically, the most commonly used method to estimate GFR is through the level of creatinine in the blood.
Creatinine is a naturally occurring metabolite that primarily comes from muscle metabolism. It is freely filtered in the renal tubules, but is also actively secreted in very small amounts. Therefore, creatinine clearance will often be higher than the actual GFR. Nevertheless, due to the convenience of measuring creatinine, this method is still widely used.
In clinical practice, estimation of GFR is crucial for assessing the excretory function of the kidneys.
Measurement and estimation of GFR
GFR can be estimated by measuring certain substances in the blood and urine, most commonly creatinine. Based on the plasma and urine concentrations of creatinine, we can calculate the GFR value. Estimated GFR (eGFR) is very common in clinical practice, especially in the staging of chronic kidney disease.
In addition to creatinine, other molecules such as glutathione C and in vitro tests of endogenous substances such as tubular clearance have also been used to measure GFR. The accuracy and feasibility of these methods are also important indicators for evaluating renal function.
The combined use of multiple methods can more accurately assess the filtration function of the kidneys.
Correlation between kidney health and GFR
The normal range of GFR is generally 90 to 120 ml per minute. When GFR values are below the normal range, it may mean that the kidneys' ability to eliminate metabolic waste is impaired. The medical community emphasizes that maintaining GFR within a healthy range can effectively prevent further deterioration of chronic kidney disease.
Changes in GFR are also often related to age, gender and other health factors. In fact, GFR naturally decreases with age, so maintaining good kidney health is especially important for older adults.
Understanding changes in GFR can help individuals make timely decisions about health management.
How to improve kidney health?
From the perspective of diet and lifestyle, proper exercise, healthy diet and regular health checks can help improve kidney health. Controlling blood pressure, blood sugar and lowering cholesterol are also very important parts of preventing kidney disease.
In addition, avoiding excessive medication use and promptly treating various diseases, such as hypertension and diabetes, can also have a positive impact on maintaining GFR in the normal range. Increasing your concern for your own health can further improve your quality of life and reduce the risk of disease.
Early health management measures can help delay the development of kidney disease.
In summary, renal tubular filtration rate (GFR) is a benchmark indicator for assessing kidney health, and understanding its changes can help us better manage our health. In your daily life, are you paying attention to your kidney health?
