A. Agin
Centre national de la recherche scientifique
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Publication
Featured researches published by A. Agin.
The Journal of Neuroscience | 2008
Laura Adela Harsan; J. Steibel; Anita Zaremba; A. Agin; R. Sapin; Patrick Poulet; Blandine Guignard; Nathalie Parizel; Daniel Grucker; Nelly Boehm; Robert H. Miller; M. Said Ghandour
The failure of the remyelination processes in multiple sclerosis contributes to the formation of chronic demyelinated plaques that lead to severe neurological deficits. Long-term cuprizone treatment of C57BL/6 mice resulted in pronounced white matter pathology characterized by oligodendrocyte depletion, irreversible demyelination and persistent functional deficits after cuprizone withdrawal. The use of a combination of in vivo diffusion tensor magnetic resonance imaging (DT-MRI) and histological analyses allowed for an accurate longitudinal assessment of demyelination. Injection of triiodothyronine (T3) hormone over a 3 week interval after cuprizone withdrawal progressively restored the normal DT-MRI phenotype accompanied by an improvement of clinical signs and remyelination. The effects of T3 were not restricted to the later stages of remyelination but increased the expression of sonic hedgehog and the numbers of Olig2+ and PSA-NCAM+ precursors and proliferative cells. Our findings establish a role for T3 as an inducer of oligodendrocyte progenitor cells in adult mouse brain following chronic demyelination.
Annales D Endocrinologie | 2013
A. Agin; Anne Charrié; Karim Chikh; Antoine Tabarin; Delphine Vezzosi
Arnaud Agin b, Anne Charrie c, Karim Chikh c, Antoine Tabarin d, Delphine Vezzosi a,∗ a Service d’endocrinologie, maladies métaboliques et nutrition, centre hospitalier universitaire Rangueil-Larrey, université Paul Sabatier et Inserm U1037 Toulouse, 31059 Toulouse cedex 09, France b Unité mixte de recherche 7004, centre national de la recherche scientifique, institut de physique biologique, faculté de médecine, université Louis-Pasteur, 67000 Strasbourg, France c Laboratoire de technique nucléaire et biophysiques, centre hospitalier Lyon-Sud, 69495 Pierre-Bénite, France d Service d’endocrinologie-diabétologie et maladies métaboliques, hôpital Haut-Lévêque, GH Sud, CHU de Bordeaux, 33604 Pessac cedex, France
Diabetes & Metabolism | 2007
A. Agin; N. Jeandidier; F. Gasser; Daniel Grucker; R. Sapin
Immuno-analyse & Biologie Specialisee | 2004
A. Agin; Françoise Gasser; E. Fischbach; J.-L. Schlienger; R. Sapin
Immuno-analyse & Biologie Specialisee | 2005
R. Sapin; P. Aberer; A. Agin; Françoise Gasser; E. Fischbach; C. Jusy
/data/revues/00034266/v74i3/S0003426613000735/ | 2013
A. Agin; Anne Charrié; Karim Chikh; Antoine Tabarin; Delphine Vezzosi
Immuno-analyse & Biologie Specialisee | 2008
R. Sapin; E. Le Guyader; A. Agin; Françoise Gasser
Immuno-analyse & Biologie Specialisee | 2007
R. Sapin; A. Agin; Françoise Gasser
Immuno-analyse & Biologie Specialisee | 2006
R. Sapin; A. Agin; Françoise Gasser
Immuno-analyse & Biologie Specialisee | 2005
A. Agin; J. Mittler; M. Offner; R. Sapin
Collaboration
Dive into the A. Agin's collaboration.
