A. Ajitha
Centre for Cellular and Molecular Biology
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Publication
Featured researches published by A. Ajitha.
European Journal of Medicinal Chemistry | 2018
Manda Sathish; Botla Kavitha; V. Lakshma Nayak; Yellaiah Tangella; A. Ajitha; Shalini Nekkanti; Abdullah Alarifi; Nagula Shankaraiah; Narayana Nagesh; Ahmed Kamal
A series of new podophyllotoxin linked β-carboline congeners have been synthesized by coupling various substituted β-carboline acids with 4β-aminopodophyllotoxin. Evaluation of their anticancer activity against a panel of human cancer cell lines such as lung cancer (A549), prostate cancer (DU-145), MDA MB-231 (breast cancer), HT-29 (colon cancer) and HeLa (cervical cancer) suggested that 7i and 7j are the most cytotoxic compounds with IC50 values of 1.07 ± 0.07 μM and 1.14 ± 0.16 respectively against DU-145 cell line. Further, detailed biological studies such as cell cycle analysis, topoisomerase II inhibition, Comet assay, DNA binding studies and docking studies have revealed that these congeners are DNA interacting topoisomerase II inhibitors.
European Journal of Medicinal Chemistry | 2018
Jeshma Kovvuri; Burri Nagaraju; V. Lakshma Nayak; Ravikumar Akunuri; M. P. Narasimha Rao; A. Ajitha; Narayan Nagesh; Ahmed E. Kamal
Archive | 2014
Asiya Begum; Shilpa K; A. Ajitha; V. Uma; Maheshwar Rao
International Journal of Pharma Research & Review | 2014
D. Saimalakondaiah; V. Ranjeet Kumar; T. Rama; Mohan Reddy; A. Ajitha; V. Uma; M. S. Rao
Archive | 2015
P. Sandhya Rani; G. Naga Sowjanya; A. Ajitha; V. Uma; Maheswara Rao; T. S India
Archive | 2015
D. Ashwini; G. Usha Sree; A. Ajitha; V. Uma Maheswara Rao
Archive | 2015
G. Swathi; A. Srividya; A. Ajitha; V. Uma; Maheswar Rao
Archive | 2015
P. Sripriya; G. Naga Sowjanya; A. Ajitha; V. Uma; Maheswara Rao
Archive | 2015
B. Varsha Rao; G. Naga Sowjanya; A. Ajitha; Maheshwara Rao; F Pha
Archive | 2015
K. Swetha; A. Ajitha; V. Uma; Maheswar Rao
Collaboration
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