A Arslanow
Saarland University
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Featured researches published by A Arslanow.
Liver International | 2016
A Arslanow; Caroline S. Stokes; Sn Weber; F Grünhage; Frank Lammert; Marcin Krawczyk
Non‐alcoholic fatty liver disease (NAFLD) is becoming the most prevalent liver disorder. The PNPLA3 (adiponutrin) variant p.I148M has been identified as common genetic modifier of NAFLD. Our aim was to assess the relationships between genetic risk and non‐invasively measured liver fat content.
Clinical and translational gastroenterology | 2016
A Arslanow; Melanie Teutsch; Hardy Walle; F Grünhage; Frank Lammert; Caroline S. Stokes
OBJECTIVES:Non-alcoholic fatty liver disease is one of the most prevalent liver diseases and increases the risk of fibrosis and cirrhosis. Current standard treatment focuses on lifestyle interventions. The primary aim of this study was to assess the effects of a short-term low-calorie diet on hepatic steatosis, using the controlled attenuation parameter (CAP) as quantitative tool.METHODS:In this prospective observational study, 60 patients with hepatic steatosis were monitored during a hypocaloric high-fiber, high-protein diet containing 1,000 kcal/day. At baseline and after 14 days, we measured hepatic fat contents using CAP during transient elastography, body composition with bioelectrical impedance analysis, and serum liver function tests and lipid profiles using standard clinical–chemical assays.RESULTS:The median age was 56 years (25–78 years); 51.7% were women and median body mass index was 31.9 kg/m2 (22.4–44.8 kg/m2). After 14 days, a significant CAP reduction (14.0%; P<0.001) was observed from 295 dB/m (216–400 dB/m) to 266 dB/m (100–353 dB/m). In parallel, body weight decreased by 4.6% (P<0.001), of which 61.9% was body fat. In addition, liver stiffness (P=0.002), γ-GT activities, and serum lipid concentrations decreased (all P<0.001).CONCLUSIONS:This study shows for the first time that non-invasive elastography can be used to monitor rapid effects of dietary treatment for hepatic steatosis. CAP improvements occur after only 14 days on short-term low-calorie diet, together with reductions of body composition parameters, serum lipids, and liver enzymes, pointing to the dynamics of hepatic lipid turnover.
Digestion | 2018
Małgorzata Jamka; A Arslanow; A Bohner; Marcin Krawczyk; Susanne Weber; F Grünhage; Frank Lammert; Caroline S. Stokes
Background/Aims: Common genetic variations in vitamin D metabolism are associated with liver stiffness. Whether these genes are implicated in hepatic steatosis remains unclear. Here we aimed to analyse the association of common vitamin D pathway gene variants with liver steatosis. Methods: Liver steatosis was assessed non-invasively in 241 patients with chronic liver conditions by controlled attenuation parameter (CAP). The following polymorphisms were genotyped using TaqMan assays: group-specific component (GC) rs7041, 7-dehydrocholesterol reductase (DHCR7) rs12785878, cytochrome P450 2R1 (CYP2R1) rs10741657, vitamin D receptor (VDR) rs7974353. Chemiluminescence immunoassay determined serum 25-hydroxyvitamin D (25(OH) D) concentrations. Results: Vitamin D deficiency (defined by 25(OH)D concentrations <20 ng/mL) occurred in 66% of patients. Median CAP was 296 (100–400) dB/m. Patients with advanced steatosis (CAP ≥280 dB/m) had significantly (p = 0.033) lower 25(OH)D levels as compared to patients with CAP <280 dB/m. Moreover, the rare allele [T] in GC rs7041 was significantly (p = 0.018) associated with higher 25(OH)D levels in patients with CAP <280 dB/m. However, GC, DHCR7, CYP2R1, and VDR polymorphisms were not related to liver steatosis and obesity traits. Conclusions: Higher CAP values are associated with low serum 25(OH)D concentrations but not with common vitamin D pathway gene variants.
Zeitschrift Fur Gastroenterologie | 2018
K Hamesch; Cv Heimes; Mattias Mandorfer; Ls Moeller; Vm Pereira; M Pons; M. Reichert; V Woditsch; J Voß; T Bretag; I Spivak; A Arslanow; M Krawczyk; Martin Wetzel; Britta Siegmund; Elmar Aigner; B Schaefer; H Zoller; T Reiberger; W Gleiber; R Bals; A Koczulla; M Miravittles; Sabina Janciauskiene; D Bzdok; J Genesca; Frank Lammert; Michael Trauner; Aleksander Krag; Christian Trautwein
Journal of Hepatology | 2014
A Arslanow; Caroline S. Stokes; S.N. Weber; F Grünhage; Frank Lammert; Marcin Krawczyk
Zeitschrift Fur Gastroenterologie | 2018
K Hamesch; Mattias Mandorfer; Ls Moeller; Vm Pereira; M Pons; M. Reichert; Cv Heimes; V Woditsch; J Voss; C Lindhauer; I Spivak; N Güldiken; A Arslanow; B Schaefer; H Zoller; Elmar Aigner; S Janciauskiene; J Genesca; Frank Lammert; Michael Trauner; Aleksander Krag; Christian Trautwein; Pavel Strnad
Journal of Hepatology | 2017
A Arslanow; M. Reichert; S. Gatter; S. Fähndrich; R. Bals; K Hamesch; Pavel Strnad; Christian Trautwein; Frank Lammert
Journal of Hepatology | 2017
M. Jamka; A Arslanow; A. Bohner; Marcin Krawczyk; S.N. Weber; F Grünhage; Frank Lammert; Caroline S. Stokes
Hepatology | 2017
Mohamad Karim Hamesch; M. Reichert; Igor Spivak; Michael H. Trauner; Robert Bals; Christian Trautwein; Aleksander Krag; Theresa Bretag; A Arslanow; Britta Siegmund; Jessica Voss; Frank Lammert; C.V. Heimes; Mattias Mandorfer; Jan Stolk; Linda Maria Sevelsted Møller; Sabina Janciauskiene; Vivien Woditsch; Pavel Strnad; Martin Wetzel
Zeitschrift Fur Gastroenterologie | 2015
A Arslanow; Caroline S. Stokes; Sn Weber; F Grünhage; Frank Lammert; Marcin Krawczyk