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Featured researches published by A Arslanow.


Liver International | 2016

The common PNPLA3 variant p.I148M is associated with liver fat contents as quantified by controlled attenuation parameter (CAP).

A Arslanow; Caroline S. Stokes; Sn Weber; F Grünhage; Frank Lammert; Marcin Krawczyk

Non‐alcoholic fatty liver disease (NAFLD) is becoming the most prevalent liver disorder. The PNPLA3 (adiponutrin) variant p.I148M has been identified as common genetic modifier of NAFLD. Our aim was to assess the relationships between genetic risk and non‐invasively measured liver fat content.


Clinical and translational gastroenterology | 2016

Short-Term Hypocaloric High-Fiber and High-Protein Diet Improves Hepatic Steatosis Assessed by Controlled Attenuation Parameter.

A Arslanow; Melanie Teutsch; Hardy Walle; F Grünhage; Frank Lammert; Caroline S. Stokes

OBJECTIVES:Non-alcoholic fatty liver disease is one of the most prevalent liver diseases and increases the risk of fibrosis and cirrhosis. Current standard treatment focuses on lifestyle interventions. The primary aim of this study was to assess the effects of a short-term low-calorie diet on hepatic steatosis, using the controlled attenuation parameter (CAP) as quantitative tool.METHODS:In this prospective observational study, 60 patients with hepatic steatosis were monitored during a hypocaloric high-fiber, high-protein diet containing 1,000 kcal/day. At baseline and after 14 days, we measured hepatic fat contents using CAP during transient elastography, body composition with bioelectrical impedance analysis, and serum liver function tests and lipid profiles using standard clinical–chemical assays.RESULTS:The median age was 56 years (25–78 years); 51.7% were women and median body mass index was 31.9 kg/m2 (22.4–44.8 kg/m2). After 14 days, a significant CAP reduction (14.0%; P<0.001) was observed from 295 dB/m (216–400 dB/m) to 266 dB/m (100–353 dB/m). In parallel, body weight decreased by 4.6% (P<0.001), of which 61.9% was body fat. In addition, liver stiffness (P=0.002), γ-GT activities, and serum lipid concentrations decreased (all P<0.001).CONCLUSIONS:This study shows for the first time that non-invasive elastography can be used to monitor rapid effects of dietary treatment for hepatic steatosis. CAP improvements occur after only 14 days on short-term low-calorie diet, together with reductions of body composition parameters, serum lipids, and liver enzymes, pointing to the dynamics of hepatic lipid turnover.


Digestion | 2018

Effects of Gene Variants Controlling Vitamin D Metabolism and Serum Levels on Hepatic Steatosis

Małgorzata Jamka; A Arslanow; A Bohner; Marcin Krawczyk; Susanne Weber; F Grünhage; Frank Lammert; Caroline S. Stokes

Background/Aims: Common genetic variations in vitamin D metabolism are associated with liver stiffness. Whether these genes are implicated in hepatic steatosis remains unclear. Here we aimed to analyse the association of common vitamin D pathway gene variants with liver steatosis. Methods: Liver steatosis was assessed non-invasively in 241 patients with chronic liver conditions by controlled attenuation parameter (CAP). The following polymorphisms were genotyped using TaqMan assays: group-specific component (GC) rs7041, 7-dehydrocholesterol reductase (DHCR7) rs12785878, cytochrome P450 2R1 (CYP2R1) rs10741657, vitamin D receptor (VDR) rs7974353. Chemiluminescence immunoassay determined serum 25-hydroxyvitamin D (25(OH) D) concentrations. Results: Vitamin D deficiency (defined by 25(OH)D concentrations <20 ng/mL) occurred in 66% of patients. Median CAP was 296 (100–400) dB/m. Patients with advanced steatosis (CAP ≥280 dB/m) had significantly (p = 0.033) lower 25(OH)D levels as compared to patients with CAP <280 dB/m. Moreover, the rare allele [T] in GC rs7041 was significantly (p = 0.018) associated with higher 25(OH)D levels in patients with CAP <280 dB/m. However, GC, DHCR7, CYP2R1, and VDR polymorphisms were not related to liver steatosis and obesity traits. Conclusions: Higher CAP values are associated with low serum 25(OH)D concentrations but not with common vitamin D pathway gene variants.


Zeitschrift Fur Gastroenterologie | 2018

Liver Fibrosis and Metabolic Alterations in Adults with Homozygous Alpha1-antitrypsin Deficiency (PiZZ Genotype)

K Hamesch; Cv Heimes; Mattias Mandorfer; Ls Moeller; Vm Pereira; M Pons; M. Reichert; V Woditsch; J Voß; T Bretag; I Spivak; A Arslanow; M Krawczyk; Martin Wetzel; Britta Siegmund; Elmar Aigner; B Schaefer; H Zoller; T Reiberger; W Gleiber; R Bals; A Koczulla; M Miravittles; Sabina Janciauskiene; D Bzdok; J Genesca; Frank Lammert; Michael Trauner; Aleksander Krag; Christian Trautwein


Journal of Hepatology | 2014

P828 THE COMMON PNPLA3 VARIANT IS ASSOCIATED WITH HEPATIC STEATOSIS QUANTIFIED BY CONTROLLED ATTENUATION PARAMETER AND DETERMINES THE FATE OF PATIENTS WITH CHRONIC LIVER DISEASES

A Arslanow; Caroline S. Stokes; S.N. Weber; F Grünhage; Frank Lammert; Marcin Krawczyk


Zeitschrift Fur Gastroenterologie | 2018

Leberfibrose und metabolische Veränderungen bei Erwachsenen mit homozygotem Alpha1-Antitrypsin-Mangel (Pi*ZZ-Genotyp) – eine europaweite Studie

K Hamesch; Mattias Mandorfer; Ls Moeller; Vm Pereira; M Pons; M. Reichert; Cv Heimes; V Woditsch; J Voss; C Lindhauer; I Spivak; N Güldiken; A Arslanow; B Schaefer; H Zoller; Elmar Aigner; S Janciauskiene; J Genesca; Frank Lammert; Michael Trauner; Aleksander Krag; Christian Trautwein; Pavel Strnad


Journal of Hepatology | 2017

Simultaneous non-invasive assessment of liver injury and body composition in alpha1-antitrypsin deficiency

A Arslanow; M. Reichert; S. Gatter; S. Fähndrich; R. Bals; K Hamesch; Pavel Strnad; Christian Trautwein; Frank Lammert


Journal of Hepatology | 2017

Effects of gene variants controlling vitamin D metabolism and serum levels on hepatic steatosis

M. Jamka; A Arslanow; A. Bohner; Marcin Krawczyk; S.N. Weber; F Grünhage; Frank Lammert; Caroline S. Stokes


Hepatology | 2017

European Cohort Reveals Liver Fibrosis and Steatosis in Adults with Homozygous Alpha1-antitrypsin Deficiency (PiZZ Genotype)

Mohamad Karim Hamesch; M. Reichert; Igor Spivak; Michael H. Trauner; Robert Bals; Christian Trautwein; Aleksander Krag; Theresa Bretag; A Arslanow; Britta Siegmund; Jessica Voss; Frank Lammert; C.V. Heimes; Mattias Mandorfer; Jan Stolk; Linda Maria Sevelsted Møller; Sabina Janciauskiene; Vivien Woditsch; Pavel Strnad; Martin Wetzel


Zeitschrift Fur Gastroenterologie | 2015

Effects of novel prosteatogenic TM6SF2 and NCAN/SUGP1 polymorphisms on hepatic steatosis and non-invasive markers of liver injury in patients with chronic liver diseases

A Arslanow; Caroline S. Stokes; Sn Weber; F Grünhage; Frank Lammert; Marcin Krawczyk

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K Hamesch

RWTH Aachen University

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Mattias Mandorfer

Medical University of Vienna

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