A. Cantarow

Production of neoplasms by injection of fractions of mammalian neoplasms.

Summary Lymphosarcomas developed in rats at the site of subcutaneous and intramedullary injection of chromatin and mitochondria fractions of the Murphy rat lymphosarcoma. Leukemia occurred in a high percentage of animals which developed local tumors following subcutaneous injection of lymphosarcoma cell fractions. Hepatomas developed in two rats at the site of intrahepatic injection of the mitochondria fraction of AAF-induced rat hepatomas. This fraction may have been contaminated with chromation fragments. Direct proof of the absence of intact cells in these fractions is impossible, but data presented seem to indicate that such contamination is highly improbable.

Glucocorticoids in adrenocortical carcinoma of mice.

Summary Adrenocortical carcinomas, induced in mice by early castration, and transplanted to recipient mice, were assayed for glucocorticoids by the mouse liver glycogen method of Venning. Glucocorticoids were present in all tumors. The hormone content of the tumors was compared with that of normal mouse adrenals and was found to be smaller on the basis of tissue weight. Incubation of tumor homogenate with desoxycorticosterone glucoside failed to yield increased glucogenic activity.