A. D. Jones
University of California, Davis
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Featured researches published by A. D. Jones.
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology | 1988
Winter Ck; H.J. Segall; A. D. Jones
1. The comparative metabolism of the pyrrolizidine alkaloid (PA) senecionine was studied in vitro in incubations of rat, guinea pig, cow, horse, and sheep hepatic microsomes. 2. Levels of the toxic pyrrolic metabolite 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) were higher from guinea pig incubations (39.9 nmol/mg protein) than from other species (range 0.07 to 7.5 nmol/mg); results disagree with prior studies which used nonspecific techniques and suggest that the guinea pigs resistance to certain PAs may be due to resistance to pyrrole toxicity rather than low pyrrole formation. 3. Minor differences in senecionine N-oxidation and hydrolysis existed between the various species.
Drug Metabolism and Disposition | 1987
Alan R. Buckpitt; N. Castagnoli; S. D. Nelson; A. D. Jones; L. S. Bahnson
Toxicology and Applied Pharmacology | 1993
Lester C. Pan; Dennis W. Wilson; Michael W. Lamé; A. D. Jones; H.J. Segall
Drug Metabolism and Disposition | 1991
J. E. Estep; Michael W. Lamé; Dexter Morin; A. D. Jones; Dennis W. Wilson; H.J. Segall
Drug Metabolism and Disposition | 1987
Winter Ck; H.J. Segall; A. D. Jones
Drug Metabolism and Disposition | 1991
Michael W. Lamé; A. D. Jones; Dexter Morin; H.J. Segall
Toxicology and Applied Pharmacology | 1997
D.W. Taylor; Dennis W. Wilson; Michael W. Lamé; S.D. Dunston; A. D. Jones; H.J. Segall
Journal of Mass Spectrometry | 1988
Winter Ck; H.J. Segall; A. D. Jones
Drug Metabolism and Disposition | 1990
Michael Buonarati; A. D. Jones; Alan R. Buckpitt
Drug Metabolism and Disposition | 1995
L S Tsuruda; Michael W. Lamé; A. D. Jones
