A. D’Onofrio

Atrial Myocardial Deformation Properties Predict Maintenance of Sinus Rhythm After External Cardioversion of Recent-Onset Lone Atrial Fibrillation A Color Doppler Myocardial Imaging and Transthoracic and Transesophageal Echocardiographic Study

Background—Accurate echocardiographic parameters to predict maintenance of sinus rhythm in patients with atrial fibrillation (AF) are poorly defined. This study was conducted to assess the atrial myocardial properties during AF through myocardial velocity, strain rate, and strain and to compare their prognostic value in maintaining sinus rhythm in patients with lone AF with standard transthoracic (TTE) and transesophageal echocardiography (TEE). Methods and Results—Sixty-five consecutive patients with lone AF for ≤3 months underwent TTE, TEE, and myocardial velocity and strain and strain rate imaging examinations before successful external cardioversion. Maintenance of sinus rhythm was assessed during a 9-month follow-up. Atrial myocardial velocity, strain, and strain rate values in AF patients were compared with those of age- and sex-matched referents. Moreover, clinical and echocardiographic parameters of patients with maintenance of sinus rhythm (MSR patients) over the 9-month follow-up period (n=25) were compared with those from patients with AF recurrence (AFR patients; n=40). Atrial myocardial properties assessed by myocardial velocity, strain rate, and strain were significantly reduced (P<0.0001) in patients (velocity, 3.2±1.4 cm/s; strain, 23.3±19%; strain rate, 2±0.9 seconds−1) compared with referents (velocity, 5.7±1.3 cm/s; strain, 92±26%; strain rate, 4.2±1.8 seconds−1). The individual predictors of sinus rhythm maintenance were atrial appendage flow velocity (MSR patients, 39±12 cm/s; AFR patients, 32±15 cm/s; P<0.01) assessed by TEE and atrial strain (MSR patients, 33±27%; AFR patients, 17±9%; P=0.0007) and strain rate (MSR patients, 2.7±1 seconds−1; AFR patients, 1.6±0.6 seconds−1; P<0.0001) peak systolic values. Atrial strain (P<0.0001; coefficient, 0.015; SE, 0.003) and strain rate (P<0.0001; coefficient, 0.372; SE, 0.075) parameters alone were confirmed as independent predictors of sinus rhythm maintenance by multivariable analysis. Conclusions—Patients with higher atrial strain and strain rate appear to have a greater likelihood of staying in sinus rhythm. If the current data are verified in future studies, then additional pharmacological therapy and maintenance of anticoagulants for a longer period may need to be considered in those with lower atrial strain and strain rate measurements.

Energy and environmental aspects of mobile communication systems

The reduction of the energy consumptions of a Telecommunication Power System represents one of the critical factors of the telecommunication technologies, both to allow a sizeable saving of economic resources and to realize “sustainable” development actions. The consumption of about one hundred base stations for mobile phones were monitored for a total of over one thousand days, in order to study the energy consumption in relation to the environmental, electric and logistics parameters of the stations themselves. It was possible to survey, then, the role of the mobile communication systems in the general national energy framework and to plot the best areas of intervention for saving energy and improving the environmental impact, showing the role played by air-conditioning and transmission equipments. Finally, new transmission algorithms and the use of renewable energy based techniques have been tested.

Cardiac fluid dynamics anticipates heart adaptation

Hemodynamic forces represent an epigenetic factor during heart development and are supposed to influence the pathology of the grown heart. Cardiac blood motion is characterized by a vortical dynamics, and it is common belief that the cardiac vortex has a role in disease progressions or regression. Here we provide a preliminary demonstration about the relevance of maladaptive intra-cardiac vortex dynamics in the geometrical adaptation of the dysfunctional heart. We employed an in vivo model of patients who present a stable normal heart function in virtue of the cardiac resynchronization therapy (CRT, bi-ventricular pace-maker) and who are expected to develop left ventricle remodeling if pace-maker was switched off. Intra-ventricular fluid dynamics is analyzed by echocardiography (Echo-PIV). Under normal conditions, the flow presents a longitudinal alignment of the intraventricular hemodynamic forces. When pacing is temporarily switched off, flow forces develop a misalignment hammering onto lateral walls, despite no other electro-mechanical change is noticed. Hemodynamic forces result to be the first event that evokes a physiological activity anticipating cardiac changes and could help in the prediction of longer term heart adaptations.

Charge state studies of low energy heavy ions passing through hydrogen and helium gas

Studies of the charge state distribution of low energy (<1.5 MeV/u), low Z (<13) heavy ions passing through hydrogen and helium gas of varying target pressure have been performed using separate windowless gas target systems at TRIUMF and the University of Naples. Semi-empirical relationships have been deduced to estimate the equilibrium charge state distributions as a function of beam energy. From these distributions, cross-sections for the relevant charge changing reactions have been deduced.

Off-line production of a 7Be radioactive ion beam

Abstract A 7 Be ion beam of several particle pA at 8 MeV has been produced at the TTT3 tandem of the University “Federico II” in Naples. The 7 Be nuclides were formed via the 7 Li(p,n) 7 Be reaction using a metallic Li target and an 11.4 MeV proton beam of 20 μA intensity, delivered by the cyclotron in Debrecen. Methods of hot chemistry were used to extract the 7 Be nuclides from the Li matrix and to prepare the 7 Be cathodes for the ion sputter source of the tandem. Examples of 7 Be beam applications are given.

Ice-core records of biomass burning

We review the approaches for estimating biomass burning from ice-cores and consider the challenges and assumptions in their application. In particular, we consider the potential of biomarker proxies for biomass burning, hitherto not widely applied to glacial ice archives. We also review the available records of biomass burning in ice-cores and consider how variations in fire regimes have been related to atmospheric and land-use changes. Finally, we suggest that future developments in ice-core science should aim to combine multiple biomarkers with other records (black carbon, charcoal) and models to discern the types of material being burnt (C3 versus C4 plants, angiosperms, gymnosperms, peat fires, etc.) and to improve constraints on source areas of biomass burning. An ultimate goal is to compare the biomass burning record from ice-cores with hindcasts from models to project how future climate change will influence biomass burning and, inversely, how fire will affect climate.

Efficacy and safety of the target-specific oral anticoagulants for stroke prevention in atrial fibrillation: the real-life evidence

The aim of our article is to provide a concise review for clinicians entailing the main studies that evaluated the efficacy and safety of target-specific oral anticoagulants (TSOAs) for thromboembolic stroke prevention in the real-world setting. Atrial fibrillation (AF) is one of the most common supraventricular arrhythmias that requires anticoagulation therapy to prevent stroke and systemic embolism. TSOAs, dabigatran, apixaban and rivaroxaban have become available as an alternative to warfarin anticoagulation in nonvalvular atrial fibrillation (NVAF). Randomized clinical trials showed non-inferior or superior results in efficacy and safety of the TSOAs compared with warfarin for stroke prevention in NVAF patients. For this reason, the 2012 update to the European Society of Cardiology guidelines for the management of AF recommends TSOAs as broadly preferable to vitamin K antagonists (VKAs) in the vast majority of patients with NVAF [Camm et al. 2012]. Although the clinical trial results and the guideline’s indications, there is a need for safety and efficacy data from unselected patients in everyday clinical practice. Recently, a large number of studies testing the efficacy and the safety of TSOAs in clinical practice have been published. The aim of our article is to provide a concise review for clinicians, outlining the main studies that evaluated the efficacy and safety of TSOAs for thromboembolic stroke prevention in the real-world setting.

Paleodiet characterisation of an Etrurian population of Pontecagnano (Italy) by Isotope Ratio Mass Spectrometry (IRMS) and Atomic Absorption Spectrometry (AAS)

Human bones recovered from the archaeological site of Pontecagnano (Salerno, Italy) have been studied to reconstruct the diet of an Etrurian population. Two different areas were investigated, named Library and Sant’ Antonio, with a total of 44 tombs containing human skeletal remains, ranging in age from the 8th to the 3rd century B.C. This time span was confirmed by 14C dating obtained using Accelerator Mass Spectrometry (AMS) on one bone sample from each site. Atomic Absorption Spectrometry (AAS) was used to extract information about the concentration of Sr, Zn, Ca elements in the bone inorganic fraction, whilst stable isotope ratio measurements (IRMS) were carried out on bone collagen to obtain the δ13C and δ15N. A reliable technique has been used to extract and separate the inorganic and organic fractions of the bone remains. Both IRMS and AAS results suggest a mixed diet including C3 plant food and herbivore animals, consistent with archaeological indications. #Revised version of a paper presented at the 1st Joint European Stable Isotope Users Group Meeting (JESIUM), August, 30 to September, 3, 2004, Vienna, Austria

Transfer of 137Cs and 60Co from irrigation water to a soil–tomato plant system

An experiment has been performed at the nuclear power plant of Garigliano (Caserta, Italy), aiming at the measurement of transfer factors of 137Cs and 60Co radionuclides from the irrigation water to a soil-plant system, with particular attention to the influence on such transfers of the irrigation technique (ground or aerial). Tomato plants were irrigated weekly with water contaminated with 137Cs and 60Co (about 375 Bq/m2 week), using both irrigation techniques. After 13 weeks, fruits, leaves, stems, roots and soil were sampled, and radionuclide concentrations were measured by high-resolution gamma spectroscopy. It was found that the activity allocated to the plant organs is significantly dependent upon the irrigation technique, amounting to 2.1% and 1.6% of the activity given in the cultivation for aerial treatment and 0.4% and 0.3% for the ground treatment, for 137Cs and 60Co respectively. The activity absorbed by plants is allocated mainly in leaves (> 55%), while less then 10% is stored in the fruits, for both irrigation techniques. Transfer factors (soil-plant and irrigation water-plant) of tomato plants and of weeds have been determined for 137Cs and 60Co, as well as for natural 40K in the soil.

Dependence of radionuclide transfer factor on growth stage for a soil-lettuce plant system

Abstract An experiment was performed at the Nuclear Power Plant of Garigliano (Caserta, Italy) to study the transfer of radionuclides from a contaminated soil to a lettuce crop and to check the validity of the generally accepted assumption of constant uptake. Measurements of specific activities of 137 Cs, 60 Co, and 40 K were periodically performed by sampling plants during a growth period of 48 days. The specific activity was analysed as a function of plant mass and growth time to gain information on the dependence of radionuclide sorption on plant growth stage. The results (time-dependent uptake rate) were interpreted using a dynamic model which generalizes the transfer factor. In this model, the time dependence of the transfer factor is characterized by three parameters obtained from a non linear least-squares fit to the data. The resulting values were found to be dependent on the radionuclide. The relative growth rate of lettuce plants plays an important role in the transport process: maximum radionuclide transport occurs at 12 d for 60 Co and 137 Cs and 28 d for 40 K.