A. García Blanco

Brachytherapy implant for patients with transurethral resection in prostate cancer

Results. From the 95 patients treated, we analyse the subgroup of 85 patients who had enough follow-up to evaluate late toxicity. The mean age at treatment was 67 (range 45–92). Most of the tumors were located at external superior cuadrant (41.2%) or joint of superior cuadrants (15.3%). Eighty per cent were infiltrating ductal carcinomas with an 84.7% of stage IA tumors and 70% of luminal A molecular subtypes. Only 6 patients were grade 3, they were treated with HDR-BT due to their age. Fifty-one patients received adjuvant hormonal therapy. Most patients (70.6%) were treated using 7 needles (range 4–12) in 2–3 planes, with a mean active length of 4.5 cm (range 2–7 cm). With a mean follow-up of 23.47 months (range 6–124), only one patient has experimented a recurrence in the ipsilateral breast 21 months after the procedure, she had a triple negative tumor and was treated with mastectomy without disease nowadays. Three patients died from another non-related disease (cerebral-vascular stroke), none of them died from breast cancer disease. Late toxicity was mild, with 27% and 5% of grade I cutaneous and subcutaneous toxicity respectively. Conclusions. Accelerated partial breast irradiation using HDR-BT is a proper approach, with excellent results in terms of disease free survival and very good tolerance in terms of normal tissue late toxicity.