A.J. Wilcox

Cumulative effects of lifetime passive smoking on cancer risk.

Cancer risk from cumulative household exposure to cigarette smoke was evaluated in a case-control study. Overall cancer risk rose steadily and significantly with each additional household member who smoked over an individuals lifetime. Cancer risk was also greater for individuals with exposures during both childhood and adulthood than for individuals with exposures during only one period. These trends were observed for both smoking-related and other sites. These findings are preliminary and must be confirmed with other studies. Nonetheless, they suggest that effects of exposure to the cigarette smoking of others may be greater than has been previously suspected.

The association of maternal factors with delayed implantation and the initial rise of urinary human chorionic gonadotrophin

BACKGROUND Late implantation and the pattern of early rise in hCG have been associated with early pregnancy loss. We explored factors that might be predictive of these markers of poor embryonic health in spontaneously conceived pregnancies. METHODS Participants in the North Carolina Early Pregnancy Study collected daily first-morning urine specimens while attempting to conceive. Samples were assayed for estrogen and progesterone metabolites (to identify day of ovulation) and hCG (to detect conception). Data were available for 190 pregnancies, 48 of which ended in early loss (within 6 weeks of the last menstrual period). We used logistic regression to identify characteristics associated with late implantation (≥10 days post-ovulation). For pregnancies surviving at least 6 weeks (n= 142), we used linear mixed models to identify factors associated with variations in hCG rise in the first 7 days from detection. RESULTS Later implantation was associated with current maternal smoking [odds ratio (OR): 5.7; 95% confidence interval (CI): 1.1-30] and with oocytes that were likely to have been fertilized late in their post-ovulatory lifespan (OR: 5.1; CI: 1.9-16). Older women had a faster rise in hCG (P= 0.01), as did women who had relatively late menarche (P for trend = 0.02). Women exposed in utero to diethylstilbestrol showed an unusual pattern of slow initial hCG rise followed by a fast increase, a pattern significantly different from that of unexposed women (P= 0.002). CONCLUSIONS Although limited by small numbers and infrequent exposures, our analyses suggest that a womans exposures both early in life and at the time of pregnancy may influence early development of the conceptus.