A. Joseph Brough

Renal Vascular Disease

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Congenital atresia and stenosis of the colon

Abstract To the 53 cases of successfully treated colonic atresia and stenosis 16 previously unreported cases are added. Resection and primary anastomosis is advocated for colonic atresia proximal to the splenic flexure, and proximal colostomy and subsequent resection and primary anastomosis is recommended for similar lesions beyond the splenic flexure. Routine contrast enema is suggested in all patients with jejunal or ileal atresia or stenosis to avoid overlooking an associated colonic atresia or stenosis. Of 209 infants operated upon for gastrointestinal atresias and stenosis, 22 or 10.5 per cent were colonic in a 22-year period. Sixteen of the 22 infants survived.

The Emily Cooley Lecture. Etiology and Pathogenesis of Acquired Hemolytic Anemia

The demonstration of recurrent lymphadenitis attributable to CMV during periods of hemolysis in a patient with chronic acquired hemolytic anemia of autoimmune type, led to the investigation of the possible etiologic relationship between this virus and acquired hemolytic anemia. In children a frequent association was demonstrated. Previously unrecognized clinical manifestations attributable to CMV were frequently observed. In this age group lymphadenopathy was a prominent finding in the majority of the cases and appeared to correspond to periods of rapid virus multiplication. It was noted that the predominant cellular lesion was not the well known pathognomonic large inclusion‐bearing cell which is a comparatively rare end state in the cellular response to the virus but less fully developed cellular lesions representing early and intermediate states. Recognition of these lesions permitted a rough appraisal of the extent of viral activity and showed that the latter generally correlated well with the hemolytic process.

The Pathophysiology of Acute Iron Poisoning

(1971). The Pathophysiology of Acute Iron Poisoning. Clinical Toxicology: Vol. 4, No. 4, pp. 585-595.

Percutaneous myocardial biopsy

Abstract A percutaneous technique for obtaining cardiac tissue with both Franklin-Vim-Silverman and Menghini needles is described. Seventy-one biopsies were attempted in 20 dogs, with cardiac tissue satisfactory for histologic analysis being obtained in 43 instances (60.5 per cent). Although the yield of specimens was higher with the FVS needle, the general impression toward the end of the study was that the Menghini needle was a more facile device in terms of ease of handling and less trauma to the subject. Cardiac tissue was obtained in 18 of 20 animals; all specimens consisted of myocardium, 4 of pericardium, and 1 of endocardium. All but 2 of 20 dogs were sacrificed 14 days after biopsy. No accumulation of pericardial fluid, significant scarring, or damage to the coronary arteries was demonstrated. The conclusion is that cardiac tissue suitable for histologic analysis can be safely obtained from the free wall of the left ventricle, at least in dogs, utilizing a percutaneous needle biopsy technique, even though several attempts may be necessary.