A. K. Goswami

Hydroxytriazenes - A Review

223 Introduction 223 Literature Survey 224 References 232

Inhibition of corrosion of Cu(II) in HNO3 using substituted hydroxytriazene

Inhibition effect of some hydroxytriazenes on copper in nitric acid medium has been studied using weight loss technique at temperature range between 303 to 343 K. The used hydroxytriazene compounds are 3-Hydroxy-3-phenyl-1-(4-sulphonato(sodium salt) phenyl) triazene(HPST), 3-Hydroxy-3-(3-methylphenyl)- 1-(4-sulphonato(sodium salt) phenyl) triazene(HMMPST), 3-Hydroxy-3-(4-methylphenyl)-1-(4-sulphonato (sodium salt) phenyl) triazene (HPMPST), 3-Hydroxy-3-(3-chloroplenyl-(4-sulphonato (sodiumsalt) phenyl) triazene (HMCPST), 3-Hydroxy-3-(4-chloroplenyl-(4-sulphonato (sodiumsalt)phenyl) triazene (HPCPST). Results reveal that inhibition efficiency increases with increasing concentration of hydroxytriazenes from 0.0005 to 0.002 M in following order HPMPST > HPST > HMMPST > HPCPST > HMCPST. HPMPST compound in 0.002M concentration show maximum inhibition efficiency of ~90 at % 303 K temperature. Effect of temperature on inhibition efficiency and thermodynamic parameters have also been reported. The adsorption of hydroxytriazenes obeyed Langmuir Adsorption Isotherm.

Antidyslipidemic and Antioxidant Effects of Novel Hydroxytriazenes

In the present investigation, a series of substituted hydroxytriazenes containing trifluoromethyl group were synthesized via diazocoupling reaction with phenylhydroxylamine. The structure of synthesized hydroxytriazenes has been assigned on the basis of elemental analysis, IR, 1H NMR and mass spectroscopy data. The lipid lowering effect of synthesized compounds was evaluated on triton-induced hyperlipidemia model in adult male Charles Foster rats. Administration of 400 mg/kg body wt. dose of triton WR 1339 causes elevation in total cholesterol, phospholipid, and triglyceride levels and inhibits post-heparin lipolytic activity, which was reversed by hydroxytriazenes. Adose of 100 mg/kg body wt. also inhibits free radical generation of superoxide anions and hydroxyl radicals and lipid oxidation.

Synthesis, characterization, theoretical prediction of activities and evaluation of biological activities of some sulfacetamide based hydroxytriazenes

Six new N [(4-aminophenyl)sulfonyl]acetamide based hydroxytriazenes have been synthesized and characterized using elemental analysis, IR, 1H NMR, 13C NMR and MASS spectral analysis. Further, their theoretical predictions for probable activities have been taken using PASS (Prediction of Activity Spectra for Substance). Although a number of activities have been predicted but specifically anti-inflammatory, antiradical, anti-diabetic activities have been experimentally validated which proves that theoretical predictions agree with the experimental results. The object of the Letter is to establish Computer Aided Drug Design (CADD) using our compounds.

Study of Binary Complex formation of Fe (III) with 3-Hydroxy-3-(phenyl)-1-2, 4Dimethyl Phenyl Triazene

The present paper reports synthesis, characterization, spectrophotometric studies and activity prediction of HPMPT with Fe (III) complexes. It was observed that Fe (III) forms complex with HPMPT in 1:3 ratio at wavelength of 510 nm and between the pH range of 4.3–4.8. The molar absorptive and Sandells sensitivity values are 52175 L mol−1 cm−1 and 1.32 ng cm−2 respectively. The study shows that metal chelates are better in activity as compared to their respective ligands. The results have been interpreted in terms of tables, figures and theories.

Analytical Application of 1, 1′-(Sulfonyldibenzene-4,1-diyl)bis(3-hydroxy-3-phenyltriaz-1-en) (BHDPT) in the Spectrophotometric Determination of Iron (III)

Bis hydroxytriazenes (1, 1′-(sulfonyldibenzene-4,1-diyl)bis(3-hydroxy-3-phenyltriaz-1-en)) has been proposed as a sensitive and selective reagent for the spectrophotometric determination of Iron(III). The method is based on the formation of green coloured 1:1 complex by the reaction of Iron (III) with Bis hydroxytriazenes. Beers law is valid over the concentration range of 1×10−4 to 4.5×10−4. The coloured complex exhibit an absorption maximum at 410 nm with molar absorptivity of 45606.2 L mol−1cm−1 and sendell sensitivity of 1.22 ng cm−2 the absorbance is found to increase linearly with increase in concentration of iron which are corroborated by the calculated correlation coefficient.