A. K. L. Wan
University of Queensland
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Featured researches published by A. K. L. Wan.
Journal of Dental Research | 2001
A. K. L. Wan; W.K. Seow; David M. Purdie; P. S. Bird; Laurence J. Walsh; David Tudehope
We hypothesize that S. mutans colonization occurs more frequently in pre-term children due to their relative immaturity. In this study of 172 predentate, six-month-old infants, we found that 50% of pre-term and 60% of full-term children harbored S. mutans. The colonization was confirmed by repeat sampling. Although there were minor differences, factors associated with S. mutans infection in pre-term and full-term infants were generally similar. In both groups, increased frequency of sugar was ranked the most important factor (p < 0.001), followed by breast-feeding (p < 0.001), and habits which allowed saliva transfer from mother to infant (p < 0.01). By contrast, non-colonization of S. mutans was associated with multiple courses of antibiotics (p < 0.001). Compared with pre-term children, there were higher percentages of full-term who had night feedings and consumed sugar during sleep times. Mothers with infected infants had S. mutans levels > 5 x 105 CFU/mL saliva (p < 0.001), poorer oral hygiene, more periodontal disease, and lower socio-economic status (p < 0.02) and snacked frequently (p < 0.001), compared with mothers with non-infected infants.
Journal of Dental Research | 2003
A. K. L. Wan; W.K. Seow; David M. Purdie; P. S. Bird; Laurence J. Walsh; David Tudehope
We previously reported that, before tooth eruption, over one-half of infants aged 6 mos were already infected with Streptococcus mutans. The aim of this investigation was to determine the colonization of S. mutans after tooth eruption in the same cohort of 111 infants (35 pre-term, 76 full-term). Our results showed that S. mutans colonization increased with increasing age, so that by 24 mos of age, 84% harbored the bacteria (p < 0.01). The mean and median ages of S. mutans colonization in dentate infants were 15.7 mos and 16.0 mos, respectively. Factors associated with S. mutans colonization were sweetened fluids taken to bed (p < 0.01), frequent sugar exposure (p < 0.03) and snacking (p < 0.03), sharing of foods with adults (p < 0.03), and maternal S. mutans levels of > 105 CFU/mL (p < 0.02). In contrast, non-colonization of S. mutans was associated with toothbrushing (p < 0.03) and multiple courses of antibiotics (p < 0.001). Analysis of our data establishes the timing of S. mutans colonization in children from birth to 24 mos of age.
Journal of Dental Research | 2001
A. K. L. Wan; W.K. Seow; Laurence J. Walsh; P. S. Bird; David Tudehope; David M. Purdie
Since dental caries may present soon after tooth eruption, we hypothesized that colonization of Streptococcus mutans can occur in the predentate stages. In this study, we examined S. mutans colonization and its association with oral developmental nodules (Bohns nodules) in 60 pre-term and 128 full-term, three-month-old infants. Overall, S. mutans was cultured from 30% (56/188) of the infants, and oral developmental nodules were noted in 55% (103/188). Compared with the pre-term, full-term infants showed a higher prevalence of S. mutans (34% vs. 20%, p < 0.02) as well as developmental nodules (61% vs. 42%, p < 0.05). In both groups, S. mutans was positively associated with numbers of developmental nodules in a dose-response relationship (p < 0.001), and with maternal salivary levels of the bacteria (p = 0.03). The permanence of S. mutans infection was confirmed by repeat saliva sampling at 6 months of age. Our results thus showed that many infants have already acquired S. mutans at 3 months of age, prior to tooth eruption.
Journal of Dental Research | 2000
W.K. Seow; A. K. L. Wan
The aim of the present investigation was to compare the dimensions of the primary incisors from pre-term children and full-term controls. One hundred and eleven pre-term children, consisting of 86 very-low-birthweight (< 1,500 g), 25 low-birthweight (from 1,500 to 2,500 g), and 169 full-term, normal-birthweight (> 2,500 g) children, donated a total of 572 maxillary and mandibular primary central and lateral incisors for study. The teeth were measured by means of a digital micrometer. The results showed that there was a dose-response effect of birthweight on tooth size. The very-low-birthweight teeth showed the smallest dimensions, the normal-birthweight controls the largest, and the low-birthweight teeth intermediate dimensions (p < 0.001). In the maxillary primary central and lateral incisors, and the mandibular primary central incisors, very-low-birthweight teeth were from 6 to 11% smaller in both mesiodistal and faciolingual dimensions compared with normal-birthweight teeth (p < 0.001). The largest differences were observed in the maxillary lateral incisors, where mean decreases of 0.58 +/- 0.45 mm in mesiodistal and 0.50 +/- 0.40 mm in faciolingual dimensions (11% reduction in both measurements) were observed. In addition, in the mandibular and maxillary lateral incisors of very-low-birthweight children, the left-sided teeth were significantly smaller than those on the right side in both mesiodistal and faciolingual dimensions (p < 0.03).
Australian Dental Journal | 2010
A. K. L. Wan; Nw Savage
BACKGROUND Biopsy procedures and diagnostic histopathology are rarely used by general dental practitioners (GDPs) compared with dental specialists. The aim of this study was to investigate the usage patterns and views of GDPs and specialists in Brisbane on these procedures. METHODS An analysis was carried out on 1027 oral biopsy accessions at a private pathology laboratory. A survey was distributed to 200 GDPs and dental specialists inquiring about their use of and views on biopsy and diagnostic histopathology. An analysis was carried out on 327 and 95 biopsies performed at a private oral medicine practice and at the University of Queensland School of Dentistry, respectively. RESULTS The majority (76.2%) of GDPs surveyed referred all oral lesions requiring biopsy to a specialist, rather than undertaking biopsy themselves. Although most GDPs recognized the importance of biopsy, a large proportion (58.1%) did not feel competent in undertaking the procedure due to concerns of inadequate experience and practical skills. CONCLUSIONS Many dental practitioners believe that GDPs should be able to undertake simple biopsies of benign lesions, however more undergraduate and postgraduate training in biopsy and diagnostic histopathology is necessary to promote a greater use of these procedures.
Australian Dental Journal | 2002
A. K. L. Wan; W.K. Seow; Laurence J. Walsh; P. S. Bird
Oral Microbiology and Immunology | 2003
A. K. L. Wan; W.K. Seow; David M. Purdie; P. S. Bird; Laurence J. Walsh; David Tudehope
Pediatric Dentistry | 1999
W.K. Seow; Amaratunge A; Sim R; A. K. L. Wan
Pediatric Dentistry | 2003
A. K. L. Wan; W.K. Seow; David M. Purdie; P. S. Bird; Laurence J. Walsh; David Tudehope
Periodontology 2000 | 2002
A. K. L. Wan; W.K. Seow; David Tudehope; David M. Purdie; Laurence J. Walsh