A. K. Sheinkman

Reaction of quinoxaline with benzopyridines in acetic anhydrides in the presence of Zn dust

The reaction between quinoxaline and benzopyridine in acetic anhydride in the presence of zinc dust gives a quinoxaline anion and a benzopyridine N-acetyl radical, which recombine to give the previously unknown N-acetyl dihydrobenzo-pyridine derivative of 1,2-dihydroquinoxaline. Under these conditions, quinoxaline alone gives 1,4-diacetyl-1,4-dihydroquinoxaline and 1-acetyl-2-(1,2-dihydroquinoxalyl-2)-1,2-dihydroquinoxaline.

Dual reactivity of 1,2-disubstituted dihydro-N-heteroaromatic systems. 9. Alkaline hydrolysis and aromatization of N-actyl partially hydrogenated derivatives of pyrazine and quinoxaline

The aromatization with splitting of the N-actyl groups of 2,3-disubstituted N-acyl-and N,N′-diacyl-1,2-dihydro-, and 1,2,3,4-tetrahydropyrazines and quinoxalines under the effect of alcohol alkali was studied. A new reaction of recyclization of 1,4-diacyl-1,2,3,4-tetrahydroquinoxaline was discovered.

Reaction of 1,4-diazines with indoles in the presence of acylating agents

Abstract2,3-Diindolyl-1,4-diacyl-1,2,3,4-tetrahydropyrazines and 2,3-diindolyl-1,2,3,4-tetrahydroquinoxalines with acyl residues attached to one or both nitrogen heteroatoms were obtained by the reaction of pyrazines and quinoxalines with indole and 1-methyl- and 2-methylindoles in the presence of acyl chlorides or acetic anhydride.

Dual reactivity of 1,2-disubstituted dihydro-N-heteroaromatic systems. 8. Aromatization of N-acyl partly hydrogenated pyrazine and quinoxaline derivatives

N-mono- and N,N-diacyl 2,3-diindolyl-substituted 1,2-dihydro- and 1,2,3,4-tetra-hydropyrazines and quinoxalines were aromatized with triphenylmethyl perchlorate and 2,2,6,6-tetramethyl-1-oxo-piperidinium perchlorate. The hitherto unknown N-acylquinoxalinium perchlorates were obtained.

New reaction for the direct incorporation of purines in nucleophilic organic compounds

The direct incorporation of purine and theophylline residues in indole, oxindole, and pyrazolone rings was accomplished in the presence of acylating agents.