A.K. Slob

SDN-POA volume, sexual behavior, and partner preference of male rats affected by perinatal treatment with ATD

The present study investigated 1) the importance of the aromatization process during the perinatal period for the development of the sexually dimorphic nucleus in the preoptic area of the hypothalamus (SDN-POA) of male rats, and 2) the relationship between SDN-POA volume and parameters of masculinization in male rats that were treated perinatally with the aromatase-inhibitor ATD. Males were treated with ATD either prenatally or pre- and neonatally, or with the vehicle. Masculine sexual behavior and partner preference were investigated in adulthood. Thereafter, animals were sacrificed and SDN-POA volume was measured. The SDN-POA volume was reduced in both the prenatally and the pre- and neonatally treated group, with a larger reduction in the latter than in the former group. Combined pre- and neonatal ATD treatment resulted in reduced frequency of mounts, intromissions, and ejaculations, as well as a reduced preference for a female over a male. The SDN-POA size was significantly and positively correlated with frequency of masculine sexual behavior, as well as preference for a female over a male.

Penile sensitivity in men with premature ejaculation and erectile dysfunction

Previous research indicates that penile sensitivity is typically lower in men with erectile dysfunction than in age-matched controls. On the assumption that sensitivity might be greater in men with short ejaculation latency (premature ejaculation), the present research investigated penile threshold (sensitivity) to vibrotactile stimulation in men with premature ejaculation, erectile dysfunction, or a combination of the two. Premature ejaculators showed thresholds commensurate with controls, while men with erectile dysfunction, or combined erectile dysfunction and premature ejaculation, showed significantly elevated thresholds. Although premature ejaculators did not show penile hypersensitivity, there was a significant correlation in this group between ejaculation latency and threshold. Overall, these findings argue against a primary role for penile sensitivity in ejaculation latency, and suggest that other somatic factors or cognitive factors may play the more critical role in premature ejaculation.

Erection Problems in Medical Practice: Differential Diagnosis with Relatively Simple Method

Functional sexual potency can be assumed when penile erection occurs during visual erotic stimulation, and to a lesser degree with normal nocturnal penile tumescence. Erection, increase in circumference as well as rigidity, can be measured with a simple device consisting of a calibrated felt band with a sliding collar fastened to 1 end. Subjects were 58 consecutive patients, mainly from a urology outpatient department, with erection problems and 67 healthy control men. Changes in penile circumference were measured during viewing of an erotic videotape and during sleep. Functional sexual potency, at least partially, was presumed to exist in 41 patients (71%), many of whom had a somatic pathological condition that might easily have been believed to be the cause of the erectile dysfunction. During the latter half of the study nocturnal penile tumescence also was measured. This group included 7 patients who did not respond to the visual stimuli, 5 of whom had normal nocturnal penile tumescence. We conclude that the erection meter, in conjunction with an erotic video test and nocturnal penile tumescence measurements, is a useful and simple device in the differential diagnosis of erectile difficulties in men. This is true especially when elaborate sleep laboratory facilities and neurophysiological equipment are not available.

Sexuality and psychophysiological functioning in women with diabetes mellitus.

Subjective and objective psychophysiological responses to erotic visual stimulation were recorded for 24 women with diabetes mellitus type I and 10 control women. There were no significant differences in subjective responses (general sexual arousal and genital arousal) between the two groups. The objective response, a rise in the temperature of the labium minus, varied with the height of the initial temperature. Since this temperature was significantly higher in diabetic women, the subsequent rise during erotic visual stimulation was less in diabetic women than in controls. When samples from the two groups were matched for initial temperature, the difference in the increase in labial temperature was no longer statistically different. In both groups of women there was a significant correlation between the degree of subjective arousal and the rise in labial temperature when women with a high temperature (greater than 37 degrees C) at the start of the visual erotic stimulation were not included. The absence of a statistically significant effect of diabetes mellitus on the parameters studied may be due to a lack of serious neuropathy and angiopathy in the present sample of diabetic women. Future psychophysiological studies should include women with serious neuropathy with or without diabetes mellitus.

Neonatal organization of adult partner preference behavior in male rats

Male rats were castrated or sham castrated shortly after birth. Castrated males were then injected every other day on days 0-10 with testosterone propionate (TP, 0.5 mg), dihydrotestosterone propionate (DHTP, 0.5 mg) or the oil vehicle (0.05 ml); sham-castrated males received oil injections. In adulthood, when substituted with DHT, DHT + E2, or T (silastic implants), sexual partner preference was measured in an automated open field (AOF), in which wire mesh prevented sexual interaction with incentives, and in a 3-compartment box (3-CB), in which sexual interaction with tethered incentives was possible. Choices were an estrous female and a nonestrous female or an estrous female and a sexually active male. In adulthood, following long-term treatment with DHT or DHT + E2, the males did not show any partner preference when sexual interaction with incentives was prevented. Following sexual experience with an estrous female these males preferred the estrous over the nonestrous female, although this change could also be due to long-term hormone treatment. In the 3-CB, a clearcut preference emerged for the estrous female over the nonestrous conspecific, although the neonatally DHTP- or oil-treated males scored lower than the neonatally TP-treated or control males. Six weeks after removal of the hormone implants, when tested in the 3-CB (estrous female vs. active male), the males showed no partner preference. Unexpectedly the control males showed a low preference for the active male. Three weeks T-treatment made all males show a preference for the estrous female (in 3-CB).(ABSTRACT TRUNCATED AT 250 WORDS)

Mutually gratifying heterosexual relationship with micropenis of husband

Three adult patients with micropenis are described: two genetic females, reared as boys, with congenital adrenocortical hyperplasia (CAH), and one male with anorchia. The patients had a male gender identity/role. All three had established a satisfying heterosexual relationship. For only one of the patients intravaginal intercourse was possible. In one patient (with CAH), penile reconstructive surgery was attempted but failed. Nevertheless, he developed a satisfactory sexual relationship with a woman friend. This report illustrates that for patients with micropenis, penile reconstructive surgery is not obligatory for the establishment of a satisfying sexual relationship.

Plasma testosterone in fetal rats and their mothers on day 19 of gestation

Plasma testosterone levels were higher in pooled samples from male fetuses than from female fetuses on day 19 of pregnancy. Plasma testosterone from female fetuses with males located caudally in the uterus was higher than from females that lacked such males. Testosterone level of both male and female fetuses was correlated with maternal testosterone. No correlation was found between maternal testosterone and number of males in the litter, male-to-female ratio, or litter size. These results corroborate earlier findings of a sex difference in plasma testosterone levels on fetal day 19 in rats, and provide support for the hypothesis that female rats receive androgens from males located caudally in the uterus. No evidence was found that testosterone of pregnant females is affected by the sex ratio or size of her litter.

The limited practical value of color Doppler sonography in the differential diagnosis of men with erectile dysfunction.

From the files of the outpatient urology department 44 men with ED had undergone both psychophysiological diagnostic screening (PDS, VSS, VSS+VIB, ICI+VSS+VIB) and color Doppler sonography testing (CDS, including VSS). PDS was carried out by one medical physiologist, CDS by one urologist. The diagnoses reached could be compared.This study revealed that CDS in ED-patients often resulted in an incorrect diagnosis, that is a presumed vascular abnormality while many such patients demonstrated firm erections under PDS-laboratory test conditions. Thus, it was concluded that CDS as a (first) screening test in ED-patients is of limited value. It was further emphasized that PDS, although giving quite relevant information about possible etiology and therapeutic treatment, is not a necessary first screen. Good history taking, preferably of the man and his partner, is still the basic first screen and quite often offers enough information to make a treatment plan with reasonable likelihood of success.

The role of the preputial glands in sexual attractivity of the female rat

This study shows that olfactory cues contribute to attractivity of the female rat but that the preputial glands are a minor source of such olfactory stimuli. In the experiments described, a residential plus-maze was used. The amount of time resident male rats spent in the vicinity of an estrous female rat was used as a measure of female attractivity. In the first experiment it was shown that male rats were attracted to anaesthetized estrous female rats but that these females were less attractive than unanaesthetized estrous females. In the second experiment it was shown that after removal of the preputial glands females were still attractive for male rats. The results of the third experiment demonstrated that estrous preputialectomized female rats remained attractive for male rats when they were anesthetized. When the resident male rats could make a choice between an estrous preputialectomized female and an estrous control female there was a tendency for the latter to be preferred. It can be concluded that olfactory cues enhance the attractivity of an estrous female rat, but that it is not the only sensory modality used by the female to attract a (distant) male. The preputial glands are of minor importance as a source of olfactory signals.

Psychosexual functioning in women with complete testicular feminization: Is androgen replacement therapy preferable to estrogen?

Effects of oral testosterone undecanoate (Andriol) on blood hormone levels, moods, sociosexual functioning and self-image of the body were studied in four gonadectomized patients with complete testicular feminization. In a double-blind cross-over experiment, patients were treated with oral testosterone undecanoate (120 mg/day) or placebo for four weeks. Peripheral blood was taken for hormone assays at the end of each four-week period. Psychosexual functioning was reported once weekly, mood scales twice weekly. In three patients testosterone treatment resulted in adult male blood levels of testosterone and estradiol. One patient did not show increased steroid levels, possibly because of hyperthyroxinaemia. No systematic effects were found on coitus, masturbation, sexual thoughts, scores on desire for bodily contact, and on attention for physical appearance. In one patient there was a marked and sustained rise in the positive moods and a fall in negative moods during androgen treatment. These results do not demonstrate that androgen therapy is preferable to estrogen in gonadectomized women with complete testicular feminization with regard to psychosexual functioning.