A. Krebs

Structure specificity of the antipsoriatic anthrones

In the investigations of Krebs and Schaltegger between 1964 and 1972 on the structure specificity of the antipsoriatic anthrones it could be shown that at least a l‐hydroxy‐9‐anthrone is necessary for their efficacy. This structure was then called ‘minimum structure of the antipsoriatic anthrones’. Since even very minor changes of this structure in most cases lead to inactive compounds, only a few antipsoriatic anthrones have been found so far. Their most important representatives chrysarobin, anthralin and 1‐hydroxy‐9‐anthrone have been known for more than 60 years. The later discovered antipsoriatic anthralin derivatives, triacetoxy‐anthracene and 10‐acyl‐anthralin, are probably hydrolysed in the skin and thus act as their parent compound anthralin. The strong structure‐activity dependence of the antipsoriatic anthrones seems to include a highly specific and complex mechanism of action.

Orale Photochemotherapie bei aktinischem Retikuloid

The successful oral photochemotherapy (PUVA) of 2 patients suffering from actinic reticuloid is reported.

On the Stability of Some Antipsoriatic Active Anthralin (Dithranol) Derivatives

The in vitro and in vivo stability of the recently presented antipsoriatic active 10-acylanthralin derivatives is investigated. These compounds are in all probability not independent drugs, but are hy

Dithranol: further investigations on the structure-activity-relationship. The new series of the 10-mono-alkyldithranol derivatives

The in vitro stability of 10-ethyldithranol (1,8-dihydroxy-10-ethyl-9(10H)-anthracenone) and its effects on healthy and psoriatic skin is investigated. 10-Ethyl-dithranol as a representative of the new class of 10-alkyldithranol derivatives neither stains nor irritates and has no antipsoriatic activity at all. This is due to the relatively stable substituent at carbon 10 which enables the fast oxidation processes necessary for the antipsoriatic effect. Therefore, antipsoriatically active dithranol derivatives require a free or easily liberated 10-position and hence the so-called minimum structure of antipsoriatic anthrones keeps its validity.

Therapeutische, funktionelle und kosmetische Spätergebnisse von 103 Patienten mit mittels Weichstrahltherapie behandelten 117 Basaliomen

We report on the therapeutic, functional and cosmetical late results of 103 patients with 117 basal-cell carcinomas treated with soft radiotherapy (total dose: 4800–6000 R). After an average of 9.1 years 95.4% of 109 controlled primary basal-cell carcinomas could be healed and of the retreated basal-cell carcinomas 62.5%. Usually slight functional disturbances were shown in 10 cases (8.5%). The cosmetical late results were judged as good or very good in 57.2%, as average in 24.8% and in 11.1% as bad, whereas big differences were made in regard of location.

Qualitative und quantitative Untersuchungen der Hautnerven bei Psoriasis

SummaryThis study was aimed at investigating the role of the nerves in the pathomechanism of psoriasis. The structure of skin nerves of 10 patients with active psoriasis and of 6 healthy control persons has been studied by means of the microscope and the electron-microscope. Eight of the patients were subjected to punch biopsies of psoritatic plaques as well as clinically normal skin.No qualitative difference could be detected between the skin nerves from psoriatic patients and from healthy persons. Quantitative investigations showed that the density of myelinated and unmyelinated axons in psoriatic skin nerves did not differ from that in normal skin nerves in a statistically significant degree. This means that the ratio of myelinated to unmyelinated axons was alike in both normal and psoriatic skin nerves. Also the diameter distribution of myelinated and unmyelinated axons was similar. The difference in the degree of myelinisation and in the myelinperiodicity between psoriatic and control skin was not statistically significant.Neither qualitative nor quantitative morphologic alterations in the skin nerves of psoriatic persons could be detected.ZusammenfassungAls Beitrag zur Aufklärung der pathogenetischen Rolle des Nervensystems bei der Schuppenflechte wurden die Hautnerven von 10 Psoriatikern und 6 Kontrollpersonen licht- und vor allem elektronenmikroskopisch untersucht und miteinander verglichen. Von den Psoriatikern wurden jeweils Biopsien aus Plaques und aus klinisch unauffälligen Hautbezirken entnommen. Bei der qualitativen Analyse ließen sich keine sicheren Unterschiede zwischen den Hautnerven von Kontrollpersonen und von Psoriatikern feststellen.Auch in der quantitativen Auswertung fanden sich keine signifikanten Unterschiede in den Hautnerven von Kontrollpersonen und von Psoriatikern in bezug auf die Dichte der myelinisierten und unmyelinisierten Axone. Auch das Verhältnis der bemarkten zu den unbemarkten Axonen ist in den drei untersuchten Gruppen nahezu gleich; dasselbe gilt für die Größenverteilung der myelinisierten und unmyelinisierten Axone. Auch Myelinisierungsgrad und Myelinperiodizität der Markfasern von Psoriatikern erwiesen sich als völlig normal.Es ließ sich weder qualitativ noch quantitativ eine Veränderung der Hautnerven bei Psoriasis nachweisen.This study was aimed at investigating the role of the nerves in the pathomechanism of psoriasis. The structure of skin nerves of 10 patients with active psoriasis and of 6 healthy control persons has been studied by means of the microscope and the electron-microscope. Eight of the patients were subjected to punch biopsies of psoritatic plaques as well as clinically normal skin. No qualitative difference could be detected between the skin nerves from psoriatic patients and from healthy persons. Quantitative investigations showed that the density of myelinated and unmyelinated axons in psoriatic skin nerves did not differ from that in normal skin nerves in a statistically significant degree. This means that the ratio of myelinated to unmyelinated axons was alike in both normal and psoriatic skin nerves. Also the diameter distribution of myelinated and unmyelinated axons was similar. The difference in the degree of myelinisation and in the myelinperiodicity between psoriatic and control skin was not statistically significant. Neither qualitative nor quantitative morphologic alterations in the skin nerves of psoriatic persons could be detected.

Diagnostische Möglichkeiten für Herpes-simplex-Virusinfektionen

Culturing herpes simplex virus is rapid and economic for establishing an etiological diagnosis. Serological tests are only of limited value. Differentiation of type I and type II strains is necessary

Vergleichende immunologische Untersuchungen der Haut-proteine bei einigen mit Schuppung einhergehenden Dermatosen

In the epidermis and scales from patients having psoriasis two proteins were found immunologically which were not present in healthy skin. These are low molecular weight and relatively stable skin pro

ATP-ase-Bestimmungen im menschlichen Spermaplasma

A quantitative photometric analysis of adenosine-triphosphatase in human seminal plasma is reported. In all the plasma investigated a decrease in the ATP-ase activity with time was found. The spermato