A. La Sala
Casa Sollievo della Sofferenza
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Publication
Featured researches published by A. La Sala.
Leukemia & Lymphoma | 2012
Fortunato Morabito; Stefan Hohaus; Corrado Mammì; Luigi Marcheselli; Massimo Gentile; Francesco Merli; Antonella Montanini; Caterina Stelitano; A. La Sala; Renato Scalone; Maria Teresa Voso; Stefano Luminari; E. Iannitto; Paolo G. Gobbi; Massimo Federico
Abstract Polymorphisms of the Glutathione-S Transferase (GST) family may influence the prognosis in lymphoma patients. We aimed to validate the impact of GSTT1 and GSTM1 deletions and of the GSTP1Ile105Val polymorphism on outcome and toxicity in 140 patients with advanced Hodgkins lymphoma enrolled in the prospective multicenter HD2000-GISL trial, comparing ABVD, BEACOPP and CEC regimens. Carriers of the GSTP1Ile105Val polymorphism had a higher rate of grade 3-4 anemia following treatment. Overall, our study failed to validate GST genotyping as prognostic factor for progression-free survival (PFS). Only the small cohort of patients with an international prognostic score (IPS) >3 and undeleted GSTT1 and/or GSTM1, treated with ABVD had worse progression-free survival (PFS) (GSTT1 + vs GSTT1−: HR 5.02, 95% C.I., 1.16–21.8, p = 0.031, GSTM1 + /GSTT1 + vs GSTM1−and/or GSTT1−: HR 4.61, 95% C.I. 1.28– 16.6, p = 0.019, respectively). No differences were observed for patients treated with intensified regimens, as BEACOPP and CEC. In conclusion, the prognostic role of GST polymorphism, if at all, is limited to a small subgroup of patients treated with standard ABVD regimen.
Journal of Clinical Oncology | 1996
Paolo G. Gobbi; C Pieresca; A Frassoldati; Mario Carotenuto; N. Di Renzo; A. La Sala; Raffaella Bertè; Paolo Avanzini; Massimo Federico; Vittorio Silingardi; Edoardo Ascari
Haematologica | 1994
L. M. A. Melillo; Nicola Cascavilla; Pellegrino Musto; M. M. Minervini; Saverio Ladogana; A. La Sala; Mario Carotenuto
Leukemia & Lymphoma | 1992
Mario Carotenuto; M. Federico; Paolo Avanzini; L. Baldini; M. Brugiatelli; L. Cavanna; N. Di Renzo; P. G. Gobbi; V. Iannitto; A. La Sala; M. Lombardo; G. Longo; F. Narni; G. Nicoletti; V. Silingardi; C. Mauri
Haematologica | 2012
Giovanni D'Arena; Luca Laurenti; G. Del Poeta; Alberto Grossi; Marta Coscia; G Mometto; Annalisa Chiarenza; Ml Vigliotti; Gabriele Pozzato; Giuseppe Nunziata; A. La Sala; Villa; Simeon; Silvia Deaglio; De Feo; Pellegrino Musto
Journal of Clinical Oncology | 2004
Pellegrino Musto; Antonietta Falcone; Grazia Sanpaolo; Carlo Bodenizza; A. La Sala; Angelo Michele Carella
Blood | 1995
Stefano Molica; A Dattilo; A Mannella; Domenico Levato; Pellegrino Musto; N. Di Renzo; A. La Sala; Mario Carotenuto
Haematologica | 1992
Mario Carotenuto; A. La Sala; Carlo Bodenizza; Angelo Michele Carella; Nicola Cascavilla; Michele Mario Greco; N. Di Renzo; Antonietta Falcone; Saverio Ladogana; Lorella Melillo; Pellegrino Musto; M. R. Sajeva
Haematologica | 1992
Antonietta Falcone; Pellegrino Musto; Michele Bisceglia; Nicola Cascavilla; Angelo Michele Carella; N. Di Renzo; Saverio Ladogana; A. La Sala; Lorella Melillo; Mario Carotenuto
Haematologica | 1992
Nicola Cascavilla; Carlo Bodenizza; N. Di Renzo; Michele Mario Greco; Saverio Ladogana; A. La Sala; Lorella Melillo; Anna Morelli; Pellegrino Musto; M. R. Sajeva; G. Salcuni; Mario Carotenuto
